Host Susceptibility to Brucella abortus Infection Is More Pronounced in IFN-γ knockout than IL-12/β2-Microglobulin Double-Deficient Mice

Brucella abortus is a facultative intracellular bacterial pathogen that causes abortion in domestic animals and undulant fever in humans. IFN-γ, IL-12, and CD8+ T lymphocytes are important components of host immune responses against B. abortus. Herein, IFN-γ and IL-12/β2-microglobulin (β2-m) knockou...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ana Paula M. S. Brandão, Fernanda S. Oliveira, Natalia B. Carvalho, Leda Q. Vieira, Vasco Azevedo, Gilson C. Macedo, Sergio C. Oliveira
Format:	Article
Language:	English
Published:	Wiley 2012-01-01
Series:	Clinical and Developmental Immunology
Online Access:	http://dx.doi.org/10.1155/2012/589494
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Investigation of the Proportion of Brucella abortus and Brucella melitensis in Sheep and Goat Milk
by: Saeid Rostami, et al.
Published: (2023-01-01)

Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in Controlling Brucella abortus Infection in Mice
by: Fernanda S. Oliveira, et al.
Published: (2012-01-01)

Persistence of Brucella abortus in the Bone Marrow of Infected Mice
by: Cristina Gutiérrez-Jiménez, et al.
Published: (2018-01-01)

Enzymatic Activity Analysis and Catalytic Essential Residues Identification of Brucella abortus Malate Dehydrogenase
by: Xiangan Han, et al.
Published: (2014-01-01)

Serological Diagnosis of <i>Brucella</i> Infection in Cetaceans by Rapid Serum Agglutination Test and Competitive ELISA with <i>Brucella abortus</i> and <i>Brucella ceti</i> as Antigens
by: Tiziana Di Febo, et al.
Published: (2025-01-01)

Blockade Effects of Anti-Interferon- (IFN-) γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity
by: Dyah Ika Krisnawati, et al.
Published: (2019-01-01)

Expression of the Gene Encoding the Brucella abortus BAB1-0278 Antigen in Probiotic Lactococcus lactis Bacteria
by: donya kazemi, et al.
Published: (2024-10-01)

Evaluation of polymorphisms at the 3´ UTR SLC11A1 gene microsatellites and their associations with the outcome of Brucella abortus infection in Bos taurus cattle
by: F.C. Hasenauer, et al.
Published: (2022-01-01)

Brucella abortus Strain RB51 Vaccine: Immune Response after Calfhood Vaccination and Field Investigation in Italian Cattle Population
by: Manuela Tittarelli, et al.
Published: (2008-01-01)

Comparison of Long-Term Antibody Titers in Calves Treated with Different Conjunctival and Subcutaneous <i>Brucella abortus</i> S19 Vaccines
by: Ali Uslu, et al.
Published: (2025-01-01)

ESTUDIO ECONÓMICO DE LA INFECCIÓN POR Brucella abortus EN GANADO BOVINO DE LA REGIÓN DEL SUMAPAZ, COLOMBIA
by: N. E. Arenas, et al.
Published: (2016-01-01)

Trueperella pyogenes and Brucella abortus Coinfection in a Dog and a Cat on a Dairy Farm in Egypt with Recurrent Cases of Mastitis and Abortion
by: Gamal Wareth, et al.
Published: (2018-01-01)

Amniotic Fluid β2- Microglobulin Measurements
by: Emine Aydın, et al.
Published: (2015-04-01)

Analysis of the IFN-γ-induced signal transduction pathway in fetal rejection
by: Irene Athanassakis
Published: (1995-01-01)

Optimizing Microneutralization and IFN-γ ELISPOT Assays to Evaluate Mpox Immunity
by: Yinyi Yu, et al.
Published: (2024-12-01)

The role of IFN-γ/CXCL10 axis in Mycoplasma pneumonia infection
by: Yanxia Zou, et al.
Published: (2025-01-01)

CD8 Knockout Mice Are Protected from Challenge by Vaccination with WR201, a Live Attenuated Mutant of Brucella melitensis
by: Samuel L. Yingst, et al.
Published: (2013-01-01)

The Different Effects of IFN-β and IFN-γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells
by: Jingchun Du, et al.
Published: (2019-01-01)

THE STUDY OF ENGLISH PHONOLOGICAL ERRORS OF ADVANCED SECOND LANGUAGE LEARNERS IN PRONOUNCING SIMILARLY-SPELLED WORDS
by: Dangin Dangin, et al.
Published: (2018-08-01)

Association between IFN-γ +874A/T and IFN-γR1 (-611A/G, +189T/G, and +95C/T) Gene Polymorphisms and Chronic Periodontitis in a Sample of Iranian Population
by: Zahra Heidari, et al.
Published: (2015-01-01)

Glutamine deprivation confers immunotherapy resistance by inhibiting IFN-γ signaling in cancer cells
by: Zhiwei Yuan, et al.
Published: (2025-03-01)

Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids
by: Akimi Yonezawa, et al.
Published: (2025-01-01)

Effects of Zearalenone on IL-2, IL-6, and IFN-γ mRNA Levels in the Splenic Lymphocytes of Chickens
by: Y. C. Wang, et al.
Published: (2012-01-01)

OsHMA3 overexpression works more efficiently in generating low-Cd rice grain than OsNramp5 knockout mutation
by: Yuejing Gui, et al.
Published: (2025-02-01)

ANALYSIS OF CELLULAR REACTION TO IFN-γ STIMULATION BY A SOFTWARE PACKAGE GeneExpressionAnalyser
by: A. V. Saetchnikov, et al.
Published: (2016-10-01)

Bronchoalveolar Lavage Fluid IFN-γ+ Th17 Cells and Regulatory T Cells in Pulmonary Sarcoidosis
by: Anders Tøndell, et al.
Published: (2014-01-01)

Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction
by: Jingyi Tan, et al.
Published: (2021-01-01)

Beta-2 microglobulin-associated amyloidosis: A forgotten link to remember
by: Javier Arias-Alcala, et al.
Published: (2025-01-01)

Upregulation of Cardiac IL-10 and Downregulation of IFN-γ in Balb/c IL-4−/− in Acute Chagasic Myocarditis due to Colombian Strain of Trypanosoma cruzi
by: Marcos Vinicius da Silva, et al.
Published: (2018-01-01)

Regulation of Chemokine CCL5 Synthesis in Human Peritoneal Fibroblasts: A Key Role of IFN-γ
by: Edyta Kawka, et al.
Published: (2014-01-01)

Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice
by: Qi Li, et al.
Published: (2019-01-01)

Phage Display-Mediated Immuno-Multiplex Quantitative PCR for the Simultaneous Quantification of IFN‑γ and IL‑6
by: Zhou Hu, et al.
Published: (2025-01-01)

IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A
by: Xiuxia Wang, et al.
Published: (2025-01-01)

Dynamic Changes of Th1 Cytokines and the Clinical Significance of the IFN-γ/TNF-α Ratio in Acute Brucellosis
by: Guang Xu, et al.
Published: (2019-01-01)

IFN-γ/TNF-α Synergism Induces Pro-Inflammatory Cytokine and Chemokine Production by In Vitro Canine Keratinocytes
by: Kyungsook Jung, et al.
Published: (2025-01-01)

Karakteristik Ibu pada Penderita Abortus dan Tidak Abortus di RS Dr. M. Djamil Padang Tahun 2011-2012
by: Resya I Noer, et al.
Published: (2016-09-01)

Influence of Inflammatory Cytokines IL-1β and IFNγ on Sarcoplasmic Aggregation of p62 and TDP-43 in Myotubes
by: Bryony McCord, et al.
Published: (2023-01-01)

TNF-α Promotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells
by: Wenyi Gu, et al.
Published: (2012-01-01)

Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children
by: Yang Zhuo, et al.
Published: (2020-01-01)

The Anthropocene Is More Than a Time Interval
by: Matthew Edgeworth, et al.
Published: (2024-07-01)