Targeting PERP promotes anti-tumor immunity in HNSCC by regulating tumor immune microenvironment and metabolic homeostasis

Targeting PERP promotes anti-tumor immunity in HNSCC by regulating tumor immune microenvironment and metabolic homeostasis

Abstract Background PERP may have the potential to function as an oncogene. However, the precise function, prognostic value, and predictive significance remain shrouded in ambiguity. Methods We conducted an in-depth analysis using pan-cancer RNA sequencing data and various online web tools to invest...

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Main Authors: Xueying Wang, Yuxi Tian, Xiaohong Wu, Yewen Zhu, Huihong Chen, Zeyao Wang, Zihan Liu, Jiaqi Tan, Zhaoyu Pan, Jiaoyan Cao, Zhenjiang Li, Xin Zhang, Zhongjie Shi, Juncheng Wang, Tong Liu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Cancer
Subjects:
PERP
Head and neck squamous cell carcinoma
Tumor microenvironment
PD1
Prognosis
Online Access:https://doi.org/10.1186/s12943-025-02360-4
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https://doi.org/10.1186/s12943-025-02360-4

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