Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis

Rose Bengal photodynamic antimicrobial therapy as an adjunct treatment for Pseudomonas aeruginosa infectious necrotizing scleritis

Purpose To report the utility of Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) as an adjunct treatment in rapidly progressing Infectious Necrotizing Scleritis (INS) secondary to Pseudomonas aeruginosa. Methods Retrospective chart review was conducted on consecutive patients with scleritis...

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Main Authors: Salomon Merikansky, Carolina Mercado, Heather Durkee, Rudolf Kobus, Juan Carlos Navia, Alejandro Arboleda, Mariela C. Aguilar, Jaime D. Martinez, Harry W. Flynn, Darlene Miller, Jean-Marie Parel, Guillermo Amescua
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Photodiagnosis and Photodynamic Therapy
Subjects:
Rose Bengal
Necrotizing scleritis
Pseudomonas aeruginosa
Photodynamic antimicrobial therapy
Sclera
Surgical debridement
Online Access:http://www.sciencedirect.com/science/article/pii/S1572100025001048
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Summary:Purpose To report the utility of Rose Bengal Photodynamic Antimicrobial Therapy (RB-PDAT) as an adjunct treatment in rapidly progressing Infectious Necrotizing Scleritis (INS) secondary to Pseudomonas aeruginosa. Methods Retrospective chart review was conducted on consecutive patients with scleritis and culture-proven Pseudomonas aeruginosa who underwent RB-PDAT. Results Six patients with Pseudomonas aeruginosa INS were included. All patients achieved complete resolution of the infection. The mean time to resolution after RB-PDAT was 17 days (range; 6–30 days), with a total treatment course average of 36 days (range; 22–60 days). One patient with pan-resistant Pseudomonas sclerokeratitis required two RB-PDAT treatments due to persistent stromal melting. All patients received a standardized regimen of oral fluoroquinolone, topical tobramycin, and ciprofloxacin/moxifloxacin. The patient with pan-resistant Pseudomonas aeruginosa required treatment with topical imipenem as well. None of the patients required enucleation. Conclusion RB-PDAT is a feasible option to halt the progression of infectious necrotizing scleritis caused by Pseudomonas aeruginosa, especially in cases of impending perforation.
ISSN:1572-1000

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