Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline.

Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline.

Adult male germline stem cells (spermatogonia) proliferate by mitosis and, after puberty, generate spermatocytes that undertake meiosis to produce haploid spermatozoa. Germ cells are under evolutionary constraint to curtail mutations and maintain genome integrity. Despite constant turnover, spermato...

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Main Authors: Eleni Giannoulatou, Geoffrey J Maher, Zhihao Ding, Ad J M Gillis, Lambert C J Dorssers, Alexander Hoischen, Ewa Rajpert-De Meyts, WGS500 Consortium, Gilean McVean, Andrew O M Wilkie, Leendert H J Looijenga, Anne Goriely
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178169&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178169&type=printable

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