Depletion-dependent activity-based protein profiling using SWATH/DIA-MS detects serine hydrolase lipid remodeling in lung adenocarcinoma progression

Depletion-dependent activity-based protein profiling using SWATH/DIA-MS detects serine hydrolase lipid remodeling in lung adenocarcinoma progression

Abstract Systematic inference of enzyme activity in human tumors is key to understanding cancer progression and resistance to therapy. However, standard protein or transcript abundances are blind to the activity status of the measured enzymes, regulated, for example, by active-site amino acid mutati...

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Main Authors: Tatjana Sajic, Matej Vizovišek, Stephan Arni, Rodolfo Ciuffa, Martin Mehnert, Sébastien Lenglet, Walter Weder, Hector Gallart-Ayala, Julijana Ivanisevic, Marija Buljan, Aurelien Thomas, Sven Hillinger, Ruedi Aebersold
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59564-x
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https://doi.org/10.1038/s41467-025-59564-x

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