Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?
Osteoporosis is the most common and serious age-related skeletal disorder, characterized by a low bone mass and bone microarchitectural deterioration, with a consequent increase in bone fragility and susceptibility to spontaneous fractures, and it represents a major worldwide health care problem wit...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2010/394579 |
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| _version_ | 1832550067403227136 |
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| author | Francesca Marini Maria Luisa Brandi |
| author_facet | Francesca Marini Maria Luisa Brandi |
| author_sort | Francesca Marini |
| collection | DOAJ |
| description | Osteoporosis is the most common and serious age-related skeletal disorder, characterized by a low bone mass and bone microarchitectural deterioration, with a consequent increase in bone fragility and susceptibility to spontaneous fractures, and it represents a major worldwide health care problem with important implications for health care costs, morbidity and mortality. Today is well accepted that osteoporosis is a multifactorial disorder caused by the interaction between environment and genes that singularly exert modest effects on bone mass and other aspects of bone strength and fracture risk. The individuation of genetic factors responsible for osteoporosis predisposition and development is fundamental for the disease prevention and for the setting of novel therapies, before fracture occurrence. In the last decades the interest of the Scientific Community has been concentrated in the understanding the genetic bases of this disease but with controversial and/or inconclusive results. This review tries to summarize data on the most representative osteoporosis candidate genes. Moreover, since recently osteoporosis and cardiovascular diseases have shown to share common physiopathological mechanisms, this review also provides information on the current understanding of osteoporosis and cardiovascular diseases common genetic bases. |
| format | Article |
| id | doaj-art-5eb4aeb43d1944a2b984dc2c8d3fc405 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-5eb4aeb43d1944a2b984dc2c8d3fc4052025-02-03T06:07:47ZengWileyInternational Journal of Hypertension2090-03922010-01-01201010.4061/2010/394579394579Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases?Francesca Marini0Maria Luisa Brandi1Department of Internal Medicine, University of Florence, Viale Pieraccini, 6, 50139 Florence, ItalyDepartment of Internal Medicine, University of Florence, Viale Pieraccini, 6, 50139 Florence, ItalyOsteoporosis is the most common and serious age-related skeletal disorder, characterized by a low bone mass and bone microarchitectural deterioration, with a consequent increase in bone fragility and susceptibility to spontaneous fractures, and it represents a major worldwide health care problem with important implications for health care costs, morbidity and mortality. Today is well accepted that osteoporosis is a multifactorial disorder caused by the interaction between environment and genes that singularly exert modest effects on bone mass and other aspects of bone strength and fracture risk. The individuation of genetic factors responsible for osteoporosis predisposition and development is fundamental for the disease prevention and for the setting of novel therapies, before fracture occurrence. In the last decades the interest of the Scientific Community has been concentrated in the understanding the genetic bases of this disease but with controversial and/or inconclusive results. This review tries to summarize data on the most representative osteoporosis candidate genes. Moreover, since recently osteoporosis and cardiovascular diseases have shown to share common physiopathological mechanisms, this review also provides information on the current understanding of osteoporosis and cardiovascular diseases common genetic bases.http://dx.doi.org/10.4061/2010/394579 |
| spellingShingle | Francesca Marini Maria Luisa Brandi Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases? International Journal of Hypertension |
| title | Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases? |
| title_full | Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases? |
| title_fullStr | Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases? |
| title_full_unstemmed | Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases? |
| title_short | Genetic Determinants of Osteoporosis: Common Bases to Cardiovascular Diseases? |
| title_sort | genetic determinants of osteoporosis common bases to cardiovascular diseases |
| url | http://dx.doi.org/10.4061/2010/394579 |
| work_keys_str_mv | AT francescamarini geneticdeterminantsofosteoporosiscommonbasestocardiovasculardiseases AT marialuisabrandi geneticdeterminantsofosteoporosiscommonbasestocardiovasculardiseases |