Mammalian fatty acid synthase: a commonly used viral host dependency factor and a putative target for host-targeted broad-spectrum antiviral therapeutic development

Mammalian fatty acid synthase: a commonly used viral host dependency factor and a putative target for host-targeted broad-spectrum antiviral therapeutic development

ABSTRACT Viruses regulate host processes to create cellular environments favorable to viral replication. At least 27 viruses that infect humans require host fatty acid synthase (FASN)-dependent de novo fatty acid biosynthesis, including viruses from the Coronaviridae, Flaviviridae, Herpesviridae, Pi...

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Bibliographic Details
Main Authors: Paola N. Loperena González, Krithika P. Karthigeyan, Jacqueline Corry, Anurup Krishna, Ben Hackenberg, Beatriz Sierra, Jesse J. Kwiek
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
virus-host interactions
FASN
antiviral pharmacology
flavivirus
coronavirus
Online Access:https://journals.asm.org/doi/10.1128/mbio.03954-24
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https://journals.asm.org/doi/10.1128/mbio.03954-24

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