Structural and functional mapping of ion access pathways in the human K+-dependent Na+/Ca2+ exchanger NCKX2 using cysteine scanning mutagenesis, thiol-modifying reagents, and homology modelling

Structural and functional mapping of ion access pathways in the human K+-dependent Na+/Ca2+ exchanger NCKX2 using cysteine scanning mutagenesis, thiol-modifying reagents, and homology modelling

K+-dependent Na+/Ca2+ exchanger proteins (NCKX) are members of the CaCA superfamily with critical roles in vision, skin pigmentation, enamel formation, and neuronal functions. Despite their importance, the structural pathways governing cation transport remain unclear. To address this, we conducted a...

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Bibliographic Details
Main Authors: Robert T. Szerencsei, Shitian Cai, Hristina R. Zhekova, Ali H. Jalloul, D. Peter Tieleman, Paul P.M. Schnetkamp
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Channels
Subjects:
NCKX2
K+-dependent Na+/Ca2+ exchangers
homology modeling
molecular dynamics
ion access pathways
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2025.2513268
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https://www.tandfonline.com/doi/10.1080/19336950.2025.2513268

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