Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestation

Abstract The cellular prion protein (PrPC) comprises a natively unstructured N‐terminal domain, including a metal‐binding octarepeat region (OR) and a linker, followed by a C‐terminal domain that misfolds to form PrPSc in Creutzfeldt‐Jakob disease. PrPC β‐endoproteolysis to the C2 fragment allows Pr...

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Main Authors: Agnes Lau, Alex McDonald, Nathalie Daude, Charles E Mays, Eric D Walter, Robin Aglietti, Robert CC Mercer, Serene Wohlgemuth, Jacques van der Merwe, Jing Yang, Hristina Gapeshina, Chae Kim, Jennifer Grams, Beipei Shi, Holger Wille, Aru Balachandran, Gerold Schmitt‐Ulms, Jiri G Safar, Glenn L Millhauser, David Westaway
Format: Article
Language:English
Published: Springer Nature 2015-02-01
Series:EMBO Molecular Medicine
Subjects:
C2
copper
endoproteolysis
octarepeats
prion
Online Access:https://doi.org/10.15252/emmm.201404588
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https://doi.org/10.15252/emmm.201404588

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