Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions
Pseudomonas aeruginosa, an antibiotic-resistant opportunistic pathogen, poses significant challenges in treating infections, particularly in immunocompromised individuals. This review explores current and future innovative approaches to suppress its growth and virulence. We delve into the bacterium’...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Cellular Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2024/7938723 |
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| _version_ | 1832546400074727424 |
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| author | Sandip Patil Xiaowen Chen Feiqiu Wen |
| author_facet | Sandip Patil Xiaowen Chen Feiqiu Wen |
| author_sort | Sandip Patil |
| collection | DOAJ |
| description | Pseudomonas aeruginosa, an antibiotic-resistant opportunistic pathogen, poses significant challenges in treating infections, particularly in immunocompromised individuals. This review explores current and future innovative approaches to suppress its growth and virulence. We delve into the bacterium’s virulence factors, discussing existing strategies like antibiotics, bacteriophages, probiotics, and small-molecule inhibitors. Additionally, novel approaches, including RNA interference, CRISPR-Cas systems, and nanotechnology, show promise in preclinical studies. Despite advancements, challenges persist, prompting the need for a multifaceted approach targeting various aspects of P. aeruginosa pathogenesis for effective infection management. This review provides a comprehensive perspective on the status and future directions of innovative strategies against P. aeruginosa. |
| format | Article |
| id | doaj-art-5e72b6ade48e4adcbd4048ce1e22ddd2 |
| institution | Kabale University |
| issn | 1462-5822 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Microbiology |
| spelling | doaj-art-5e72b6ade48e4adcbd4048ce1e22ddd22025-02-03T06:55:34ZengWileyCellular Microbiology1462-58222024-01-01202410.1155/2024/7938723Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future DirectionsSandip Patil0Xiaowen Chen1Feiqiu Wen2Department of Haematology and OncologyDepartment of Haematology and OncologyDepartment of Haematology and OncologyPseudomonas aeruginosa, an antibiotic-resistant opportunistic pathogen, poses significant challenges in treating infections, particularly in immunocompromised individuals. This review explores current and future innovative approaches to suppress its growth and virulence. We delve into the bacterium’s virulence factors, discussing existing strategies like antibiotics, bacteriophages, probiotics, and small-molecule inhibitors. Additionally, novel approaches, including RNA interference, CRISPR-Cas systems, and nanotechnology, show promise in preclinical studies. Despite advancements, challenges persist, prompting the need for a multifaceted approach targeting various aspects of P. aeruginosa pathogenesis for effective infection management. This review provides a comprehensive perspective on the status and future directions of innovative strategies against P. aeruginosa.http://dx.doi.org/10.1155/2024/7938723 |
| spellingShingle | Sandip Patil Xiaowen Chen Feiqiu Wen Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions Cellular Microbiology |
| title | Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions |
| title_full | Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions |
| title_fullStr | Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions |
| title_full_unstemmed | Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions |
| title_short | Innovative Approaches to Suppressing Pseudomonas aeruginosa Growth and Virulence: Current Status and Future Directions |
| title_sort | innovative approaches to suppressing pseudomonas aeruginosa growth and virulence current status and future directions |
| url | http://dx.doi.org/10.1155/2024/7938723 |
| work_keys_str_mv | AT sandippatil innovativeapproachestosuppressingpseudomonasaeruginosagrowthandvirulencecurrentstatusandfuturedirections AT xiaowenchen innovativeapproachestosuppressingpseudomonasaeruginosagrowthandvirulencecurrentstatusandfuturedirections AT feiqiuwen innovativeapproachestosuppressingpseudomonasaeruginosagrowthandvirulencecurrentstatusandfuturedirections |