A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms
Blue light induced eye damage (BLED) belongs to modern diseases. It is an ophthalmic disease caused by prolonged exposure to electronic devices or screens containing a large amount of high-energy short waves (blue light). Specific symptoms include dryness and discomfort in the eyes, blurred vision,...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1513406/full |
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| author | Yuan Yan Yuan Yan Yuan Yan Yiyao Wu Yiyao Wu Yiyao Wu Yu Zhao Yu Zhao Yu Zhao Yaguang Yang Yaguang Yang Yaguang Yang Guangtao An Guangtao An Guangtao An Zhidong Liu Zhidong Liu Zhidong Liu Zhidong Liu Dongli Qi Dongli Qi Dongli Qi |
| author_facet | Yuan Yan Yuan Yan Yuan Yan Yiyao Wu Yiyao Wu Yiyao Wu Yu Zhao Yu Zhao Yu Zhao Yaguang Yang Yaguang Yang Yaguang Yang Guangtao An Guangtao An Guangtao An Zhidong Liu Zhidong Liu Zhidong Liu Zhidong Liu Dongli Qi Dongli Qi Dongli Qi |
| author_sort | Yuan Yan |
| collection | DOAJ |
| description | Blue light induced eye damage (BLED) belongs to modern diseases. It is an ophthalmic disease caused by prolonged exposure to electronic devices or screens containing a large amount of high-energy short waves (blue light). Specific symptoms include dryness and discomfort in the eyes, blurred vision, headache, insomnia, and in severe cases, it may also cause various eye diseases such as cataracts and glaucoma. At present, the development of health products and drugs for eye blue light injury faces many difficulties. Therefore, further exploration and research are needed on the pathogenesis, pathophysiology, and pharmacological mechanisms of blue light injury. Natural medicine ingredients and preparations have unique advantages in targeting eye blue light injury fatigue products due to their multi-component synergistic effects, overall regulation, and mild and safe characteristics. Starting from the disease-related mechanisms and pathophysiological characteristics of eye blue light injury, this article elucidates the pharmacological mechanisms of various drugs for treating eye blue light injury. At the same time, it reviews the research on in vitro cultured cell and animal model conditions for blue light injury eyes, in order to provide reference for subsequent blue light injury modeling experiments. And explore future research directions to provide new ideas and methods for the prevention and treatment of BLED. |
| format | Article |
| id | doaj-art-5e5c253dfff54f3b9e815aa449e0bc1f |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-5e5c253dfff54f3b9e815aa449e0bc1f2025-01-23T06:56:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.15134061513406A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanismsYuan Yan0Yuan Yan1Yuan Yan2Yiyao Wu3Yiyao Wu4Yiyao Wu5Yu Zhao6Yu Zhao7Yu Zhao8Yaguang Yang9Yaguang Yang10Yaguang Yang11Guangtao An12Guangtao An13Guangtao An14Zhidong Liu15Zhidong Liu16Zhidong Liu17Zhidong Liu18Dongli Qi19Dongli Qi20Dongli Qi21Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaHaihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaHaihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaHaihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaHaihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaHaihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaCollege of Chinese Medicine, Tianjin University of Chinese Medicine, Tianjin, ChinaHaihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaEngineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaBlue light induced eye damage (BLED) belongs to modern diseases. It is an ophthalmic disease caused by prolonged exposure to electronic devices or screens containing a large amount of high-energy short waves (blue light). Specific symptoms include dryness and discomfort in the eyes, blurred vision, headache, insomnia, and in severe cases, it may also cause various eye diseases such as cataracts and glaucoma. At present, the development of health products and drugs for eye blue light injury faces many difficulties. Therefore, further exploration and research are needed on the pathogenesis, pathophysiology, and pharmacological mechanisms of blue light injury. Natural medicine ingredients and preparations have unique advantages in targeting eye blue light injury fatigue products due to their multi-component synergistic effects, overall regulation, and mild and safe characteristics. Starting from the disease-related mechanisms and pathophysiological characteristics of eye blue light injury, this article elucidates the pharmacological mechanisms of various drugs for treating eye blue light injury. At the same time, it reviews the research on in vitro cultured cell and animal model conditions for blue light injury eyes, in order to provide reference for subsequent blue light injury modeling experiments. And explore future research directions to provide new ideas and methods for the prevention and treatment of BLED.https://www.frontiersin.org/articles/10.3389/fphar.2025.1513406/fulleyeblue light damagepharmacological mechanismmodeling conditionsresearch direction |
| spellingShingle | Yuan Yan Yuan Yan Yuan Yan Yiyao Wu Yiyao Wu Yiyao Wu Yu Zhao Yu Zhao Yu Zhao Yaguang Yang Yaguang Yang Yaguang Yang Guangtao An Guangtao An Guangtao An Zhidong Liu Zhidong Liu Zhidong Liu Zhidong Liu Dongli Qi Dongli Qi Dongli Qi A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms Frontiers in Pharmacology eye blue light damage pharmacological mechanism modeling conditions research direction |
| title | A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms |
| title_full | A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms |
| title_fullStr | A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms |
| title_full_unstemmed | A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms |
| title_short | A review on eye diseases induced by blue light: pathology, model, active ingredients and mechanisms |
| title_sort | review on eye diseases induced by blue light pathology model active ingredients and mechanisms |
| topic | eye blue light damage pharmacological mechanism modeling conditions research direction |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1513406/full |
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