Birch reductive arylation by mechanochemical anionic activation of polycyclic aromatic compounds

Abstract Birch reduction is a well-known process for transforming aromatic compounds. The reduction of aromatic rings using alkali metals produces anionic species that react with protons or electrophiles. Generally, this reaction is accompanied by significant limitations in the available nucleophile...

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Bibliographic Details
Main Authors: Yoshifumi Toyama, Akiko Yagi, Kenichiro Itami, Hideto Ito
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60318-y
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