The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further Study
HIV and malaria have similar global distributions. Annually, 500 million are infected and 1 million die because of malaria. 33 million have HIV and 2 million die from it each year. Minor effects of one infection on the disease course or outcome for the other would significantly impact public health...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2009/617954 |
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| author | Sarah Hochman Kami Kim |
| author_facet | Sarah Hochman Kami Kim |
| author_sort | Sarah Hochman |
| collection | DOAJ |
| description | HIV and malaria have similar global distributions. Annually, 500 million are infected and 1 million die because of malaria. 33 million have HIV and 2 million die from it each year. Minor effects of one infection on the disease course or outcome for the other would significantly impact public health because of the sheer number of people at risk for coinfection. While early population-based studies showed no difference in outcomes between HIV-positive and HIV-negative individuals with malaria, more recent work suggests that those with HIV have more frequent episodes of symptomatic malaria and that malaria increases HIV plasma viral load and decreases CD4+ T cells. HIV and malaria each interact with the host's immune system, resulting in a complex activation of immune cells, and subsequent dysregulated production of cytokines and antibodies. Further investigation of these interactions is needed to better define effects of coinfection. |
| format | Article |
| id | doaj-art-5e5a77d871b947d2973a5c5df1b75bf5 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-5e5a77d871b947d2973a5c5df1b75bf52025-02-03T01:23:59ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982009-01-01200910.1155/2009/617954617954The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further StudySarah Hochman0Kami Kim1Department of Medicine, Division of Infectious Diseases, Montefiore Medical Center, Albert Einstein College of Medicine, Ullmann 1205, 1300 Morris Park Avenue, Bronx, NY 10461, USADepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Ullmann 1225, 1300 Morris Park Avenue, Bronx, NY 10461, USAHIV and malaria have similar global distributions. Annually, 500 million are infected and 1 million die because of malaria. 33 million have HIV and 2 million die from it each year. Minor effects of one infection on the disease course or outcome for the other would significantly impact public health because of the sheer number of people at risk for coinfection. While early population-based studies showed no difference in outcomes between HIV-positive and HIV-negative individuals with malaria, more recent work suggests that those with HIV have more frequent episodes of symptomatic malaria and that malaria increases HIV plasma viral load and decreases CD4+ T cells. HIV and malaria each interact with the host's immune system, resulting in a complex activation of immune cells, and subsequent dysregulated production of cytokines and antibodies. Further investigation of these interactions is needed to better define effects of coinfection.http://dx.doi.org/10.1155/2009/617954 |
| spellingShingle | Sarah Hochman Kami Kim The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further Study Interdisciplinary Perspectives on Infectious Diseases |
| title | The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further Study |
| title_full | The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further Study |
| title_fullStr | The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further Study |
| title_full_unstemmed | The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further Study |
| title_short | The Impact of HIV and Malaria Coinfection: What Is Known and Suggested Venues for Further Study |
| title_sort | impact of hiv and malaria coinfection what is known and suggested venues for further study |
| url | http://dx.doi.org/10.1155/2009/617954 |
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