Emulating a Target Trial of Early Compared to Late Initiation of Appropriate Antibiotic Therapy for Hospital-acquired Monobacterial Gram-negative Blood Stream Infections

Emulating a Target Trial of Early Compared to Late Initiation of Appropriate Antibiotic Therapy for Hospital-acquired Monobacterial Gram-negative Blood Stream Infections

Background: Considering the difficulties and ethical concerns to conduct a randomized controlled trial comparing early appropriate antimicrobial treatment (<24h) versus late initiation of appropriate therapy (24-72h) in Gram-negative bacterial (GNB) infections, we conducted a target trial emulati...

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Bibliographic Details
Main Authors: Abdullah Tarik Aslan, Yukiko Ezure, Elif Seren Tanriverdi, Osman Dag, Cansu Cimen, Baris Otlu, Patrick Harris, Murat Akova, David L. Paterson
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Target trial
emulation
Gram-negative bacteraemia
early appropriate therapy
mortality
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716524001978
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