Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)
The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 wee...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/592760 |
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| author | Liliana Ferreira Edite Teixeira-de-Lemos Filipa Pinto Belmiro Parada Cristina Mega Helena Vala Rui Pinto Patrícia Garrido José Sereno Rosa Fernandes Paulo Santos Isabel Velada Andreia Melo Sara Nunes Frederico Teixeira Flávio Reis |
| author_facet | Liliana Ferreira Edite Teixeira-de-Lemos Filipa Pinto Belmiro Parada Cristina Mega Helena Vala Rui Pinto Patrícia Garrido José Sereno Rosa Fernandes Paulo Santos Isabel Velada Andreia Melo Sara Nunes Frederico Teixeira Flávio Reis |
| author_sort | Liliana Ferreira |
| collection | DOAJ |
| description | The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (control) and sitagliptin (10 mg/kg/bw). Glucose, HbA1c, insulin, Total-c, TGs, IL-1β, TNF-α, CRPhs, and adiponectin were assessed in serum and MDA and TAS in serum, pancreas, and heart. Pancreatic histology was also evaluated. Sitagliptin in diabetic rats promoted a decrease in glucose, HbA1c, Total-c, and TGs accompanied by a partial prevention of insulinopenia, together, with a decrease in CRPhs and IL-1β. Sitagliptin also showed a positive impact on lipid peroxidation and hypertension prevention. In conclusion, chronic sitagliptin treatment corrected the glycaemic dysmetabolism, hypertriglyceridaemia, inflammation, and hypertension, reduced the severity of the histopathological lesions of pancreatic endocrine and exocrine tissues, together with a favourable redox status, which might be a further advantage in the management of diabetes and its proatherogenic comorbidities. |
| format | Article |
| id | doaj-art-5e43eb060b7247a8a26f7dd40d904990 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5e43eb060b7247a8a26f7dd40d9049902025-02-03T01:21:37ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/592760592760Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)Liliana Ferreira0Edite Teixeira-de-Lemos1Filipa Pinto2Belmiro Parada3Cristina Mega4Helena Vala5Rui Pinto6Patrícia Garrido7José Sereno8Rosa Fernandes9Paulo Santos10Isabel Velada11Andreia Melo12Sara Nunes13Frederico Teixeira14Flávio Reis15Institute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalESAV, Polytechnic Institute of Viseu, 3500 Viseu, PortugalESAV, Polytechnic Institute of Viseu, 3500 Viseu, PortugalPharmacology & Pharmacotoxicology Unit, Faculty of Pharmacy, Lisbon University, 1649-003 Lisboa, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalFunctional Genomics Laboratory, Center of Histocompatibility of the Centre, 3001-301 Coimbra, PortugalFunctional Genomics Laboratory, Center of Histocompatibility of the Centre, 3001-301 Coimbra, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalInstitute of Pharmacology & Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, PortugalThe purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (control) and sitagliptin (10 mg/kg/bw). Glucose, HbA1c, insulin, Total-c, TGs, IL-1β, TNF-α, CRPhs, and adiponectin were assessed in serum and MDA and TAS in serum, pancreas, and heart. Pancreatic histology was also evaluated. Sitagliptin in diabetic rats promoted a decrease in glucose, HbA1c, Total-c, and TGs accompanied by a partial prevention of insulinopenia, together, with a decrease in CRPhs and IL-1β. Sitagliptin also showed a positive impact on lipid peroxidation and hypertension prevention. In conclusion, chronic sitagliptin treatment corrected the glycaemic dysmetabolism, hypertriglyceridaemia, inflammation, and hypertension, reduced the severity of the histopathological lesions of pancreatic endocrine and exocrine tissues, together with a favourable redox status, which might be a further advantage in the management of diabetes and its proatherogenic comorbidities.http://dx.doi.org/10.1155/2010/592760 |
| spellingShingle | Liliana Ferreira Edite Teixeira-de-Lemos Filipa Pinto Belmiro Parada Cristina Mega Helena Vala Rui Pinto Patrícia Garrido José Sereno Rosa Fernandes Paulo Santos Isabel Velada Andreia Melo Sara Nunes Frederico Teixeira Flávio Reis Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) Mediators of Inflammation |
| title | Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) |
| title_full | Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) |
| title_fullStr | Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) |
| title_full_unstemmed | Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) |
| title_short | Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat) |
| title_sort | effects of sitagliptin treatment on dysmetabolism inflammation and oxidative stress in an animal model of type 2 diabetes zdf rat |
| url | http://dx.doi.org/10.1155/2010/592760 |
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