Investigating the underlying mechanisms of the ethanol extract of saussureae involucratae herba in anti-rheumatoid arthritis effect based on sphingolipidomics

Investigating the underlying mechanisms of the ethanol extract of saussureae involucratae herba in anti-rheumatoid arthritis effect based on sphingolipidomics

IntroductionSaussureae Involucratae Herba (SIH), a traditional Chinese Medicine, is clinically used in treating rheumatoid arthritis (RA). However, the anti-RA mechanisms of SIH remain unclear. Dysregulation of sphingolipid metabolism is related to the pathogenesis of RA. This study aims to investig...

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Main Authors: Pingyuan Chi, Hairong Zhang, Yingjie Chen, Jianhua Xie, Yiming Ayixianmuguli, Caisheng Wu, Mingyuan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
saussureae involucratae herba
sphingolipidomics
rheumatoid arthritis
HPLC-MS/MS
S1P signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1549437/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1549437/full

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