The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus
Metabolic diseases, especially diabetes mellitus, have become global health issues. The etiology of diabetes mellitus can be attributed to genetic and/or environmental factors. Current evidence suggests the association of gut microbiota with metabolic diseases. However, the effects of glucose-loweri...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/1890978 |
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| author | You Lv Xue Zhao Weiying Guo Ying Gao Shuo Yang Zhuo Li Guixia Wang |
| author_facet | You Lv Xue Zhao Weiying Guo Ying Gao Shuo Yang Zhuo Li Guixia Wang |
| author_sort | You Lv |
| collection | DOAJ |
| description | Metabolic diseases, especially diabetes mellitus, have become global health issues. The etiology of diabetes mellitus can be attributed to genetic and/or environmental factors. Current evidence suggests the association of gut microbiota with metabolic diseases. However, the effects of glucose-lowering agents on gut microbiota are poorly understood. Several studies revealed that these agents affect the composition and diversity of gut microbiota and consequently improve glucose metabolism and energy balance. Possible underlying mechanisms include affecting gene expression, lowering levels of inflammatory cytokines, and regulating the production of short-chain fatty acids. In addition, gut microbiota may alleviate adverse effects caused by glucose-lowering agents, and this can be especially beneficial in diabetic patients who experience severe gastrointestinal side effects and have to discontinue these agents. In conclusion, gut microbiota may provide a novel viewpoint for the treatment of patients with diabetes mellitus. |
| format | Article |
| id | doaj-art-5e241c2f8b9044dda25318c414e7b1c7 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-5e241c2f8b9044dda25318c414e7b1c72025-02-03T06:44:22ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/18909781890978The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes MellitusYou Lv0Xue Zhao1Weiying Guo2Ying Gao3Shuo Yang4Zhuo Li5Guixia Wang6Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin, ChinaMetabolic diseases, especially diabetes mellitus, have become global health issues. The etiology of diabetes mellitus can be attributed to genetic and/or environmental factors. Current evidence suggests the association of gut microbiota with metabolic diseases. However, the effects of glucose-lowering agents on gut microbiota are poorly understood. Several studies revealed that these agents affect the composition and diversity of gut microbiota and consequently improve glucose metabolism and energy balance. Possible underlying mechanisms include affecting gene expression, lowering levels of inflammatory cytokines, and regulating the production of short-chain fatty acids. In addition, gut microbiota may alleviate adverse effects caused by glucose-lowering agents, and this can be especially beneficial in diabetic patients who experience severe gastrointestinal side effects and have to discontinue these agents. In conclusion, gut microbiota may provide a novel viewpoint for the treatment of patients with diabetes mellitus.http://dx.doi.org/10.1155/2018/1890978 |
| spellingShingle | You Lv Xue Zhao Weiying Guo Ying Gao Shuo Yang Zhuo Li Guixia Wang The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus Journal of Diabetes Research |
| title | The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus |
| title_full | The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus |
| title_fullStr | The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus |
| title_full_unstemmed | The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus |
| title_short | The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus |
| title_sort | relationship between frequently used glucose lowering agents and gut microbiota in type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2018/1890978 |
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