Development of a new high-yield integration site assay reveals disease-specific patterns across HTLV-1-associated pathologies

Development of a new high-yield integration site assay reveals disease-specific patterns across HTLV-1-associated pathologies

ABSTRACT Human T lymphotropic virus type 1 (HTLV-1) chronic infection is maintained through mitotic proliferation of the infected CD4+ T cells, where the viral genome is integrated as a provirus in its host genome. HTLV-1 integration sites (ISs) have a part in HTLV-1-associated pathologies, with dis...

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Main Authors: Vincent Guiraud, Jérôme Alexandre Denis, Sofia Ben Attia, Erwan Ablin, Ronan Legrand, Véronique Morel, Claire Lacan, Sylvain Choquet, Rabab Debs, Margaux Cheval, Cindy Marques, Alexandre Le Joncour, Jean-Christophe Corvol, Olivier Benveniste, Valérie Pourcher, Anne-Geneviève Marcelin, Agnès Gautheret-Dejean, Clotilde Bravetti, Vincent Calvez
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
HTLV-1
Integration Site
ISLA
panhandle PCR
clonal proliferation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03208-24
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https://journals.asm.org/doi/10.1128/spectrum.03208-24

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