Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma
We present a case report of a male with multifocal and extensive basal cell carcinoma. Due to extremely large size and deep tumor infiltration, he was not a surgical candidate. Combined modality treatment of fractionated radiation with concurrent vismodegib was chosen. Concurrent treatment was previ...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/2354146 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552296448262144 |
|---|---|
| author | Abigail I. Franco Gary Eastwick Ramsay Farah Marvin Heyboer Mijung Lee Paul Aridgides |
| author_facet | Abigail I. Franco Gary Eastwick Ramsay Farah Marvin Heyboer Mijung Lee Paul Aridgides |
| author_sort | Abigail I. Franco |
| collection | DOAJ |
| description | We present a case report of a male with multifocal and extensive basal cell carcinoma. Due to extremely large size and deep tumor infiltration, he was not a surgical candidate. Combined modality treatment of fractionated radiation with concurrent vismodegib was chosen. Concurrent treatment was previously reported in the palliative and recurrent setting. This is the first case of concurrent vismodegib and radiation therapy for upfront definitive management. The patient experienced complete response in all treated lesions. |
| format | Article |
| id | doaj-art-5de255cd08ba4b4a945bca2ad8090f50 |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-5de255cd08ba4b4a945bca2ad8090f502025-02-03T05:58:57ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712018-01-01201810.1155/2018/23541462354146Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell CarcinomaAbigail I. Franco0Gary Eastwick1Ramsay Farah2Marvin Heyboer3Mijung Lee4Paul Aridgides5St. Joseph’s Hospital Health Center, 301 Prospect Avenue, Syracuse, NY 13203, USAUpstate University Hospital, 750 E. Adams Street, Syracuse, NY 13210, USAUpstate University Hospital, 750 E. Adams Street, Syracuse, NY 13210, USAUpstate University Hospital, 750 E. Adams Street, Syracuse, NY 13210, USAUpstate University Hospital, 750 E. Adams Street, Syracuse, NY 13210, USAUpstate University Hospital, 750 E. Adams Street, Syracuse, NY 13210, USAWe present a case report of a male with multifocal and extensive basal cell carcinoma. Due to extremely large size and deep tumor infiltration, he was not a surgical candidate. Combined modality treatment of fractionated radiation with concurrent vismodegib was chosen. Concurrent treatment was previously reported in the palliative and recurrent setting. This is the first case of concurrent vismodegib and radiation therapy for upfront definitive management. The patient experienced complete response in all treated lesions.http://dx.doi.org/10.1155/2018/2354146 |
| spellingShingle | Abigail I. Franco Gary Eastwick Ramsay Farah Marvin Heyboer Mijung Lee Paul Aridgides Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma Case Reports in Dermatological Medicine |
| title | Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma |
| title_full | Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma |
| title_fullStr | Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma |
| title_full_unstemmed | Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma |
| title_short | Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma |
| title_sort | upfront radiotherapy with concurrent and adjuvant vismodegib is effective and well tolerated in a patient with advanced multifocal basal cell carcinoma |
| url | http://dx.doi.org/10.1155/2018/2354146 |
| work_keys_str_mv | AT abigailifranco upfrontradiotherapywithconcurrentandadjuvantvismodegibiseffectiveandwelltoleratedinapatientwithadvancedmultifocalbasalcellcarcinoma AT garyeastwick upfrontradiotherapywithconcurrentandadjuvantvismodegibiseffectiveandwelltoleratedinapatientwithadvancedmultifocalbasalcellcarcinoma AT ramsayfarah upfrontradiotherapywithconcurrentandadjuvantvismodegibiseffectiveandwelltoleratedinapatientwithadvancedmultifocalbasalcellcarcinoma AT marvinheyboer upfrontradiotherapywithconcurrentandadjuvantvismodegibiseffectiveandwelltoleratedinapatientwithadvancedmultifocalbasalcellcarcinoma AT mijunglee upfrontradiotherapywithconcurrentandadjuvantvismodegibiseffectiveandwelltoleratedinapatientwithadvancedmultifocalbasalcellcarcinoma AT paularidgides upfrontradiotherapywithconcurrentandadjuvantvismodegibiseffectiveandwelltoleratedinapatientwithadvancedmultifocalbasalcellcarcinoma |