Graded response of the pulmonary circulation to progressive pulmonary embolism in sheep: From compensation to lethal right heart failure

Graded response of the pulmonary circulation to progressive pulmonary embolism in sheep: From compensation to lethal right heart failure

Background: Severe pulmonary embolism (PE) with right heart failure (RHF) has high mortality. To more fully understand PE progression, we evaluated the right ventricle (RV) and pulmonary circulation response to graded PE in an acute PE sheep model. Methods: Polydextran beads were intravenously admin...

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Main Authors: Cheng Zhou, MD, Yuman Li, MD, Kyle Polley, Cherry Ballard-Croft, PhD, Masashi Kawabori, MD, Keshava Rajagopal, MD, PhD, Joseph B. Zwischenberger, MD, Dongfang Wang, MD, PhD
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:JHLT Open
Subjects:
pulmonary embolism
right heart failure
sheep
pressure-volume loop
pulmonary artery impedance
Online Access:http://www.sciencedirect.com/science/article/pii/S2950133425000552
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