Large-bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenarians
Abstract Purpose To evaluate outcomes in patients aged ≥ 80 years following large-bore aspiration thrombectomy (LBAT) for the treatment of pulmonary embolism (PE). Materials and methods All patients ≥ 80 years of age with PE treated via LBAT at a single center were analyzed from September 2019 – Aug...
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SpringerOpen
2025-01-01
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| Series: | CVIR Endovascular |
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| Online Access: | https://doi.org/10.1186/s42155-025-00517-2 |
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| author | Reid Masterson Travis Pebror Andrew Gauger Adam William Schmitz Sabah David Butty |
| author_facet | Reid Masterson Travis Pebror Andrew Gauger Adam William Schmitz Sabah David Butty |
| author_sort | Reid Masterson |
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| description | Abstract Purpose To evaluate outcomes in patients aged ≥ 80 years following large-bore aspiration thrombectomy (LBAT) for the treatment of pulmonary embolism (PE). Materials and methods All patients ≥ 80 years of age with PE treated via LBAT at a single center were analyzed from September 2019 – August 2024. This included the octogenarian subgroup from a recently published retrospective analysis assessing all PE patients treated with LBAT at our center between September 2019 and January 2023. The following outcomes were evaluated: technical success, change in several hemodynamic measures including pulmonary artery pressure (PAP) and right ventricle to left ventricle ratio (RV to LV ratio), length of hospital and intensive-care-unit (ICU) stay, procedure-related complications, and 7- and 30-day mortality. Results Forty-eight patients aged ≥ 80 years underwent LBAT procedures for PE. Technical success was achieved in 46 cases (95.8%). The mean reduction in mean PAP was 3.6 mmHg. The mean reduction in RV to LV ratio was -0.42. The mean length of postprocedural hospital and ICU stays were 5.7 ± 3.6 days and 1.0 ± 1.6 days, respectively. There were 2 procedural complications, 1 pulmonary vascular injury involving a pulmonary artery pseudoaneurysm and 1 decompensation involving hypotension requiring vasopressor support. There were no major bleeding complications or cardiac injuries. All-cause mortality was 2.1% (n = 1) at 7 days and 6.3% (n = 3) at 30 days post procedure. PE-related mortality was 2.1% (n = 1) at 30 days. Conclusion LBAT is a technically feasible procedure for the treatment of PE in octogenarian patients and has a favorable preliminary safety and mortality profile. |
| format | Article |
| id | doaj-art-5d26384322ea463ba56eb83cc8a38a9f |
| institution | Kabale University |
| issn | 2520-8934 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
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| series | CVIR Endovascular |
| spelling | doaj-art-5d26384322ea463ba56eb83cc8a38a9f2025-01-26T12:54:09ZengSpringerOpenCVIR Endovascular2520-89342025-01-01811510.1186/s42155-025-00517-2Large-bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenariansReid Masterson0Travis Pebror1Andrew Gauger2Adam William Schmitz3Sabah David Butty4Department of Radiology and Imaging Sciences, Indiana University School of MedicineDepartment of Radiology and Imaging Sciences, Indiana University School of MedicineDepartment of Radiology and Imaging Sciences, Indiana University School of MedicineDepartment of Radiology and Imaging Sciences, Indiana University School of MedicineDepartment of Radiology and Imaging Sciences, Indiana University School of MedicineAbstract Purpose To evaluate outcomes in patients aged ≥ 80 years following large-bore aspiration thrombectomy (LBAT) for the treatment of pulmonary embolism (PE). Materials and methods All patients ≥ 80 years of age with PE treated via LBAT at a single center were analyzed from September 2019 – August 2024. This included the octogenarian subgroup from a recently published retrospective analysis assessing all PE patients treated with LBAT at our center between September 2019 and January 2023. The following outcomes were evaluated: technical success, change in several hemodynamic measures including pulmonary artery pressure (PAP) and right ventricle to left ventricle ratio (RV to LV ratio), length of hospital and intensive-care-unit (ICU) stay, procedure-related complications, and 7- and 30-day mortality. Results Forty-eight patients aged ≥ 80 years underwent LBAT procedures for PE. Technical success was achieved in 46 cases (95.8%). The mean reduction in mean PAP was 3.6 mmHg. The mean reduction in RV to LV ratio was -0.42. The mean length of postprocedural hospital and ICU stays were 5.7 ± 3.6 days and 1.0 ± 1.6 days, respectively. There were 2 procedural complications, 1 pulmonary vascular injury involving a pulmonary artery pseudoaneurysm and 1 decompensation involving hypotension requiring vasopressor support. There were no major bleeding complications or cardiac injuries. All-cause mortality was 2.1% (n = 1) at 7 days and 6.3% (n = 3) at 30 days post procedure. PE-related mortality was 2.1% (n = 1) at 30 days. Conclusion LBAT is a technically feasible procedure for the treatment of PE in octogenarian patients and has a favorable preliminary safety and mortality profile.https://doi.org/10.1186/s42155-025-00517-2OctogenarianAdvanced agePulmonary embolismThrombectomyReperfusion therapy |
| spellingShingle | Reid Masterson Travis Pebror Andrew Gauger Adam William Schmitz Sabah David Butty Large-bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenarians CVIR Endovascular Octogenarian Advanced age Pulmonary embolism Thrombectomy Reperfusion therapy |
| title | Large-bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenarians |
| title_full | Large-bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenarians |
| title_fullStr | Large-bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenarians |
| title_full_unstemmed | Large-bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenarians |
| title_short | Large-bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenarians |
| title_sort | large bore aspiration thrombectomy for the treatment of pulmonary embolism in octogenarians |
| topic | Octogenarian Advanced age Pulmonary embolism Thrombectomy Reperfusion therapy |
| url | https://doi.org/10.1186/s42155-025-00517-2 |
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