Use of oral midodrine for weaning off norepinephrine in patients with septic shock
Abstract Background Early administration of norepinephrine in septic shock patients is linked to better survival rates. However, vasopressor dependence often occurs during the recovery phase, delaying ICU discharge. Objectives A comparative study was conducted on patients admitted with a diagnosis o...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Egyptian Journal of Critical Care Medicine |
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| Online Access: | https://doi.org/10.1007/s44349-024-00013-x |
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| author | Mohamed Obaya Randa Soliman Alia Abdelfattah Moamen Arafa |
| author_facet | Mohamed Obaya Randa Soliman Alia Abdelfattah Moamen Arafa |
| author_sort | Mohamed Obaya |
| collection | DOAJ |
| description | Abstract Background Early administration of norepinephrine in septic shock patients is linked to better survival rates. However, vasopressor dependence often occurs during the recovery phase, delaying ICU discharge. Objectives A comparative study was conducted on patients admitted with a diagnosis of septic shock over 2 years regarding the use of oral midodrine in weaning them off norepinephrine. Patients and methods The population in this study included 100 patients admitted to the adult ICU department with septic shock between October 2016 and August 2018. Participants were divided into two cohorts: Group I was administered only IV norepinephrine, whereas Group II was given both IV norepinephrine and midodrine. Participants in the midodrine group were administered 10 mg of midodrine orally every 8 h. Results Results showed that patients not receiving oral midodrine had higher NE doses, longer NE infusion duration, extended NE weaning time, and increased ICU and hospital stay compared to those who did receive oral midodrine (p < 0.001). Our study indicates that oral midodrine was not a predictor of survival rate (p = 0.964). Conclusions Midodrine may serve as a valuable adjunct for weaning from IV vasopressors in septic shock patients. Septic shock patients who received midodrine for IV norepinephrine weaning showed significantly lower NE doses, durations of NE infusion, and NE weaning times. |
| format | Article |
| id | doaj-art-5d194b782c264d1696c22f3d766752d3 |
| institution | Kabale University |
| issn | 2090-7303 2090-9209 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Egyptian Journal of Critical Care Medicine |
| spelling | doaj-art-5d194b782c264d1696c22f3d766752d32025-01-19T12:14:17ZengSpringerEgyptian Journal of Critical Care Medicine2090-73032090-92092025-01-011211710.1007/s44349-024-00013-xUse of oral midodrine for weaning off norepinephrine in patients with septic shockMohamed Obaya0Randa Soliman1Alia Abdelfattah2Moamen Arafa3Critical Care Department, Faculty of Medicine, Cairo UniversityCritical Care Department, Faculty of Medicine, Cairo UniversityCritical Care Department, Faculty of Medicine, Cairo UniversityCritical Care Department, Faculty of Medicine, Cairo UniversityAbstract Background Early administration of norepinephrine in septic shock patients is linked to better survival rates. However, vasopressor dependence often occurs during the recovery phase, delaying ICU discharge. Objectives A comparative study was conducted on patients admitted with a diagnosis of septic shock over 2 years regarding the use of oral midodrine in weaning them off norepinephrine. Patients and methods The population in this study included 100 patients admitted to the adult ICU department with septic shock between October 2016 and August 2018. Participants were divided into two cohorts: Group I was administered only IV norepinephrine, whereas Group II was given both IV norepinephrine and midodrine. Participants in the midodrine group were administered 10 mg of midodrine orally every 8 h. Results Results showed that patients not receiving oral midodrine had higher NE doses, longer NE infusion duration, extended NE weaning time, and increased ICU and hospital stay compared to those who did receive oral midodrine (p < 0.001). Our study indicates that oral midodrine was not a predictor of survival rate (p = 0.964). Conclusions Midodrine may serve as a valuable adjunct for weaning from IV vasopressors in septic shock patients. Septic shock patients who received midodrine for IV norepinephrine weaning showed significantly lower NE doses, durations of NE infusion, and NE weaning times.https://doi.org/10.1007/s44349-024-00013-xSeptic shockNorepinephrineMidodrineMortality |
| spellingShingle | Mohamed Obaya Randa Soliman Alia Abdelfattah Moamen Arafa Use of oral midodrine for weaning off norepinephrine in patients with septic shock Egyptian Journal of Critical Care Medicine Septic shock Norepinephrine Midodrine Mortality |
| title | Use of oral midodrine for weaning off norepinephrine in patients with septic shock |
| title_full | Use of oral midodrine for weaning off norepinephrine in patients with septic shock |
| title_fullStr | Use of oral midodrine for weaning off norepinephrine in patients with septic shock |
| title_full_unstemmed | Use of oral midodrine for weaning off norepinephrine in patients with septic shock |
| title_short | Use of oral midodrine for weaning off norepinephrine in patients with septic shock |
| title_sort | use of oral midodrine for weaning off norepinephrine in patients with septic shock |
| topic | Septic shock Norepinephrine Midodrine Mortality |
| url | https://doi.org/10.1007/s44349-024-00013-x |
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