A systematic review and meta-analysis of phase III randomized controlled trials to assess the risk of pneumonia, URTIs, and VTE in multiple myeloma patients treated with isatuximab

A systematic review and meta-analysis of phase III randomized controlled trials to assess the risk of pneumonia, URTIs, and VTE in multiple myeloma patients treated with isatuximab

Background: Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow, constituting approximately 13% of all hematologic malignancies. Isatuximab is a monoclonal antibody targeting the CD38 protein on myeloma cells, causi...

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Main Authors: Daniel Thomas Jones, Hazem Aboaid, Ramaditya Srinivasmurthy, Kevin Nguyen, Rishi Kumar Nanda, Jason Ta, Benjamin Tzer-Ming Chuang, Yin Mon Myat, Aishwarya Hanspal, Kyaw Zin Thein, Thura Win Htut
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2025-03-01
Series:Exploration of Targeted Anti-tumor Therapy
Subjects:
multiple myeloma
isatuximab
pneumonia
upper respiratory tract infections (urtis)
venous thromboembolism (vte)
randomized controlled trials (rcts)
adverse events
hematologic malignancy
Online Access:https://www.explorationpub.com/uploads/Article/A1002300/1002300.pdf
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