Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity
A series of novel thiazolyl hydrazine derivatives 3a–3o were synthesized and evaluated for their in vitro antifungal activity against six phytopathogenic strains, namely, Botryosphaeria dothidea (B. d.), Gibberella sanbinetti (G. s.), Fusarium oxysporum (F. o.), Thanatephorus cucumeris (T. c.), Scle...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2021/6563871 |
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| author | Jianjun Zhu Yazhen Chen Fen Su Peiyi Wang |
| author_facet | Jianjun Zhu Yazhen Chen Fen Su Peiyi Wang |
| author_sort | Jianjun Zhu |
| collection | DOAJ |
| description | A series of novel thiazolyl hydrazine derivatives 3a–3o were synthesized and evaluated for their in vitro antifungal activity against six phytopathogenic strains, namely, Botryosphaeria dothidea (B. d.), Gibberella sanbinetti (G. s.), Fusarium oxysporum (F. o.), Thanatephorus cucumeris (T. c.), Sclerotinia sclerotiorum (S. s.), and Verticillium dahliae (V. d.), by the classical mycelial growth rate method. Biological assessment results showed that most of these target compounds showed good antifungal activity toward tested strains. Especially, compound 3l showed excellent antifungal activities against B. d. and G. s. with relatively lower EC50 values of 0.59 and 0.69 µg/mL, respectively, which were extremely superior to those of commercial fungicides fluopyram, boscalid, and hymexazol and were comparable to those of carbendazim. Given the excellent bioactivity of designed compounds, this kind of thiazolyl hydrazine framework can provide a suitable point for exploring highly efficient antifungal agents. |
| format | Article |
| id | doaj-art-5ca7fcbf0955417eb678b114611dce3d |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-5ca7fcbf0955417eb678b114611dce3d2025-02-03T01:24:44ZengWileyJournal of Chemistry2090-90632090-90712021-01-01202110.1155/2021/65638716563871Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal ActivityJianjun Zhu0Yazhen Chen1Fen Su2Peiyi Wang3State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R & D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R & D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R & D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaState Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R & D of Fine Chemicals of Guizhou University, Guiyang 550025, ChinaA series of novel thiazolyl hydrazine derivatives 3a–3o were synthesized and evaluated for their in vitro antifungal activity against six phytopathogenic strains, namely, Botryosphaeria dothidea (B. d.), Gibberella sanbinetti (G. s.), Fusarium oxysporum (F. o.), Thanatephorus cucumeris (T. c.), Sclerotinia sclerotiorum (S. s.), and Verticillium dahliae (V. d.), by the classical mycelial growth rate method. Biological assessment results showed that most of these target compounds showed good antifungal activity toward tested strains. Especially, compound 3l showed excellent antifungal activities against B. d. and G. s. with relatively lower EC50 values of 0.59 and 0.69 µg/mL, respectively, which were extremely superior to those of commercial fungicides fluopyram, boscalid, and hymexazol and were comparable to those of carbendazim. Given the excellent bioactivity of designed compounds, this kind of thiazolyl hydrazine framework can provide a suitable point for exploring highly efficient antifungal agents.http://dx.doi.org/10.1155/2021/6563871 |
| spellingShingle | Jianjun Zhu Yazhen Chen Fen Su Peiyi Wang Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity Journal of Chemistry |
| title | Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity |
| title_full | Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity |
| title_fullStr | Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity |
| title_full_unstemmed | Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity |
| title_short | Synthesis of Novel Thiazolyl Hydrazine Derivatives and Their Antifungal Activity |
| title_sort | synthesis of novel thiazolyl hydrazine derivatives and their antifungal activity |
| url | http://dx.doi.org/10.1155/2021/6563871 |
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