Platelet specific knockout of integrin beta-3 (β3) reduces severity of necrotizing enterocolitis in murine neonates

Platelet specific knockout of integrin beta-3 (β3) reduces severity of necrotizing enterocolitis in murine neonates

IntroductionNecrotizing Enterocolitis (NEC) is the most impactful gastrointestinal disease of premature neonates and preclinical evidence shows that the event of platelet activation is an important pathophysiological contributor during NEC-like injury in murine neonates. Integrin αIIb/β3 (glycoprote...

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Main Authors: Marie Amalie Balamurugan, Balamurugan Ramatchandirin, Suneetha Desiraju, Arjun Subrramanya, Juanitaa George Raj, Megan M. Ferris, Zainab D. Lawal, Oluwabunmi O. Olaloye, Liza Konnikova, Krishnan MohanKumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pediatrics
Subjects:
necrotizing enterocolitis
integrin beta-3
platelet
monocyte
platelet-monocyte aggregation
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2025.1560242/full
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https://www.frontiersin.org/articles/10.3389/fped.2025.1560242/full

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