Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model
To date, failed back surgery syndrome (FBSS) remains a therapy-refractory clinical condition after spinal surgery. The antiadhesion membrane is applied to prevent FBSS by isolating fibrosis; however, the inflammation stimulated by the foreign body and surgical trauma needs to be further resolved sim...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/6684176 |
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| author | Wei Wang Yunhao Wang Tengfei Lou Mingqian Ding Juehong Li Hao Xiong Zhixiao Yao Yingying Ma Huajiang Chen Shenghe Liu |
| author_facet | Wei Wang Yunhao Wang Tengfei Lou Mingqian Ding Juehong Li Hao Xiong Zhixiao Yao Yingying Ma Huajiang Chen Shenghe Liu |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | To date, failed back surgery syndrome (FBSS) remains a therapy-refractory clinical condition after spinal surgery. The antiadhesion membrane is applied to prevent FBSS by isolating fibrosis; however, the inflammation stimulated by the foreign body and surgical trauma needs to be further resolved simultaneously. Therefore, we developed new electrospun polycaprolactone (PCL) fibrous membranes loaded with celecoxib (CEL) to prevent fibrosis and inflammation associated with FBSS. The CEL-loaded PCL fibers were randomly distributed, and the drug was released over two weeks. Fluorescence micrographs revealed that the fibroblasts proliferated less on the PCL-CEL fibrous membranes than in the PCL group and the blank control. In the rat laminectomy model after 4 weeks, magnetic resonance imaging of epidural fibrosis was least in the PCL-CEL group. Expression of COX-2 and PGE2 was lower in the PCL-CEL group. It concluded that the CEL-loaded PCL membrane could reduce fibrosis and inflammation in a rat model of FBSS via COX-2/PGE2 signaling pathways. |
| format | Article |
| id | doaj-art-5c74b1cd30f244539064baa36714e494 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-5c74b1cd30f244539064baa36714e4942025-02-03T01:29:20ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/66841766684176Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome ModelWei Wang0Yunhao Wang1Tengfei Lou2Mingqian Ding3Juehong Li4Hao Xiong5Zhixiao Yao6Yingying Ma7Huajiang Chen8Shenghe Liu9Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, ChinaDepartment of Spinal Surgery, Changzheng Hospital Affiliated to Second Military Medical University, 415 Fengyang Road, Shanghai 200003, ChinaDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, ChinaTaian TSCM Hospital, No. 265 Lingshan Street, Taian, Shandong 271000, ChinaDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, ChinaDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, ChinaDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, ChinaDepartment of Medical Engineering, Shandong Provincial Hospital Affiliated to Shandong University, 423 5th Longitude Crossing 7th Latitude Road, Shandong 250021, ChinaDepartment of Spinal Surgery, Changzheng Hospital Affiliated to Second Military Medical University, 415 Fengyang Road, Shanghai 200003, ChinaDepartment of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, ChinaTo date, failed back surgery syndrome (FBSS) remains a therapy-refractory clinical condition after spinal surgery. The antiadhesion membrane is applied to prevent FBSS by isolating fibrosis; however, the inflammation stimulated by the foreign body and surgical trauma needs to be further resolved simultaneously. Therefore, we developed new electrospun polycaprolactone (PCL) fibrous membranes loaded with celecoxib (CEL) to prevent fibrosis and inflammation associated with FBSS. The CEL-loaded PCL fibers were randomly distributed, and the drug was released over two weeks. Fluorescence micrographs revealed that the fibroblasts proliferated less on the PCL-CEL fibrous membranes than in the PCL group and the blank control. In the rat laminectomy model after 4 weeks, magnetic resonance imaging of epidural fibrosis was least in the PCL-CEL group. Expression of COX-2 and PGE2 was lower in the PCL-CEL group. It concluded that the CEL-loaded PCL membrane could reduce fibrosis and inflammation in a rat model of FBSS via COX-2/PGE2 signaling pathways.http://dx.doi.org/10.1155/2021/6684176 |
| spellingShingle | Wei Wang Yunhao Wang Tengfei Lou Mingqian Ding Juehong Li Hao Xiong Zhixiao Yao Yingying Ma Huajiang Chen Shenghe Liu Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model Neural Plasticity |
| title | Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model |
| title_full | Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model |
| title_fullStr | Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model |
| title_full_unstemmed | Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model |
| title_short | Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGE2 Induced Inflammation and Epidural Fibrosis in a Rat Failed Back Surgery Syndrome Model |
| title_sort | celecoxib loaded electrospun fibrous antiadhesion membranes reduce cox 2 pge2 induced inflammation and epidural fibrosis in a rat failed back surgery syndrome model |
| url | http://dx.doi.org/10.1155/2021/6684176 |
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