NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming

NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming

Abstract Purpose Cancer cells rely on serine biosynthesis for growth, but its regulation in colorectal cancer (CRC) remains not well understood. This study identifies the m5C methyltransferase NSUN2 (NOP2/Sun domain family, member 2) as a key regulator of serine biosynthesis, revealing a novel mecha...

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Bibliographic Details
Main Authors: Hao Li, Tingyue Gong, Yongheng Zhao, Yang Luo, Shuibin Tang, Tingfeng Wang, Haiping Lin, Ming Zhong
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cancer & Metabolism
Subjects:
5-methylcytosine modification
Colorectal cancer
NSUN2
PHGDH
Serine metabolism
Online Access:https://doi.org/10.1186/s40170-025-00406-1
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https://doi.org/10.1186/s40170-025-00406-1

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