Suppressing TLR4 alleviates cerebral injury in heatstroke rats through the modulation of microglial polarization

Suppressing TLR4 alleviates cerebral injury in heatstroke rats through the modulation of microglial polarization

Objective This study aims to explore the neuroprotective effects of inhibiting TLR4 on brain damage resulting from heatstroke (HS) and to clarify the underlying molecular mechanisms involved.Methods In this study, we successfully established a HS rat model. The TLR4 antagonist TAK-242 was administer...

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Bibliographic Details
Main Authors: Xiaomin Wu, Ting He, Chunli Yang, Shujing Xue, Qianqian Yuan, Feifei Chen, Juan Liu, Guanghua Li
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:International Journal of Hyperthermia
Subjects:
Heatstroke
toll-like receptor 4
TAK-242
microglia
polarization
Online Access:https://www.tandfonline.com/doi/10.1080/02656736.2025.2503312
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https://www.tandfonline.com/doi/10.1080/02656736.2025.2503312

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