P2X 7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study

P2X 7-receptor binding in new-onset and secondary progressive MS – a [11C]SMW139 PET study

Abstract Background PET imaging of activated microglia has improved our understanding of the pathology behind disability progression in MS, and pro-inflammatory microglia at ‘smoldering’ lesion rims have been implicated as drivers of disability progression. The P2X 7R is upregulated in the cellular...

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Main Authors: Jussi Lehto, Richard Aarnio, Jouni Tuisku, Marcus Sucksdorff, Esa Mikko Koivumäki, Marjo Nylund, Semi Helin, Johan Rajander, Jonathan Danon, Jayson Gilchrist, Michael Kassiou, Vesa Oikonen, Laura Airas
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:EJNMMI Research
Subjects:
Multiple sclerosis
Microglia
PET
Kinetic modelling
Online Access:https://doi.org/10.1186/s13550-024-01186-3
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