Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing

Membrane transporter progressive ankylosis protein homologue (ANKH/Ank) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing

IntroductionA considerable body of recent evidence supports citrate transport as a major regulator of organismal lifespan and healthspan. Citrate accumulates outside senescent cells in vitro and in vivo. However, the detailed mechanism of senescent cell extracellular citrate (EC) accumulation is not...

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Main Authors: Emma Naomi James, Muy-Teck Teh, Yufeng Li, Christine Wagner-Bock, Zahra Falah Al-Khateeb, Lee Peng Karen-Ng, Terry Roberts, Linnea Synchyshyn, Amy Lewis, Ana O’Loghlen, Andrew Silver, Adina Teodora Michael-Titus, Mark Bennett, Jacob Guy Bundy, Maria Elzbieta Mycielska, Eric Kenneth Parkinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Aging
Subjects:
ANKH/SLC62A1
citrate
senescence
ageing
inflammation
astrocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2025.1583288/full
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https://www.frontiersin.org/articles/10.3389/fragi.2025.1583288/full

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