Bacteriophages: A Challenge for Antimicrobial Therapy
Phage therapy, which involves the use of bacteriophages (phages) to combat bacterial infections, is emerging as a promising approach to address the escalating threat posed by multidrug-resistant (MDR) bacteria. This brief review examines the historical background and recent advancements in phage res...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/1/100 |
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| author | Nallelyt Segundo-Arizmendi Dafne Arellano-Maciel Abraham Rivera-Ramírez Adán Manuel Piña-González Gamaliel López-Leal Efren Hernández-Baltazar |
| author_facet | Nallelyt Segundo-Arizmendi Dafne Arellano-Maciel Abraham Rivera-Ramírez Adán Manuel Piña-González Gamaliel López-Leal Efren Hernández-Baltazar |
| author_sort | Nallelyt Segundo-Arizmendi |
| collection | DOAJ |
| description | Phage therapy, which involves the use of bacteriophages (phages) to combat bacterial infections, is emerging as a promising approach to address the escalating threat posed by multidrug-resistant (MDR) bacteria. This brief review examines the historical background and recent advancements in phage research, focusing on their genomics, interactions with host bacteria, and progress in medical and biotechnological applications. Additionally, we expose key aspects of the mechanisms of action, and therapeutic uses of phage considerations in treating MDR bacterial infections are discussed, particularly in the context of infections related to virus–bacteria interactions. |
| format | Article |
| id | doaj-art-5be1469bc72a48a58d9fe7a38e6a71ba |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-5be1469bc72a48a58d9fe7a38e6a71ba2025-01-24T13:42:38ZengMDPI AGMicroorganisms2076-26072025-01-0113110010.3390/microorganisms13010100Bacteriophages: A Challenge for Antimicrobial TherapyNallelyt Segundo-Arizmendi0Dafne Arellano-Maciel1Abraham Rivera-Ramírez2Adán Manuel Piña-González3Gamaliel López-Leal4Efren Hernández-Baltazar5Laboratorio de Microbiología y Parasitología, Facultad de Farmacia de la, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, MexicoLaboratorio de Biología Computacional y Virómica Integrativa, Centro de Investigación en Dinámica Celular, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, MexicoLaboratorio de Estudios Ecogenómicos, Centro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, MexicoLaboratorio de Biología Computacional y Virómica Integrativa, Centro de Investigación en Dinámica Celular, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, MexicoLaboratorio de Biología Computacional y Virómica Integrativa, Centro de Investigación en Dinámica Celular, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, MexicoLaboratorio 1 de Tecnología Farmacéutica, Facultad de Farmacia de la, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, MexicoPhage therapy, which involves the use of bacteriophages (phages) to combat bacterial infections, is emerging as a promising approach to address the escalating threat posed by multidrug-resistant (MDR) bacteria. This brief review examines the historical background and recent advancements in phage research, focusing on their genomics, interactions with host bacteria, and progress in medical and biotechnological applications. Additionally, we expose key aspects of the mechanisms of action, and therapeutic uses of phage considerations in treating MDR bacterial infections are discussed, particularly in the context of infections related to virus–bacteria interactions.https://www.mdpi.com/2076-2607/13/1/100phage therapymultidrug-resistant bacteria (MDR)antimicrobial resistancephage-based therapeuticsCRISPRphage stability |
| spellingShingle | Nallelyt Segundo-Arizmendi Dafne Arellano-Maciel Abraham Rivera-Ramírez Adán Manuel Piña-González Gamaliel López-Leal Efren Hernández-Baltazar Bacteriophages: A Challenge for Antimicrobial Therapy Microorganisms phage therapy multidrug-resistant bacteria (MDR) antimicrobial resistance phage-based therapeutics CRISPR phage stability |
| title | Bacteriophages: A Challenge for Antimicrobial Therapy |
| title_full | Bacteriophages: A Challenge for Antimicrobial Therapy |
| title_fullStr | Bacteriophages: A Challenge for Antimicrobial Therapy |
| title_full_unstemmed | Bacteriophages: A Challenge for Antimicrobial Therapy |
| title_short | Bacteriophages: A Challenge for Antimicrobial Therapy |
| title_sort | bacteriophages a challenge for antimicrobial therapy |
| topic | phage therapy multidrug-resistant bacteria (MDR) antimicrobial resistance phage-based therapeutics CRISPR phage stability |
| url | https://www.mdpi.com/2076-2607/13/1/100 |
| work_keys_str_mv | AT nallelytsegundoarizmendi bacteriophagesachallengeforantimicrobialtherapy AT dafnearellanomaciel bacteriophagesachallengeforantimicrobialtherapy AT abrahamriveraramirez bacteriophagesachallengeforantimicrobialtherapy AT adanmanuelpinagonzalez bacteriophagesachallengeforantimicrobialtherapy AT gamaliellopezleal bacteriophagesachallengeforantimicrobialtherapy AT efrenhernandezbaltazar bacteriophagesachallengeforantimicrobialtherapy |