Toll-like receptor 2-mediated ERK activation significantly upregulates interleukin-6 expression in M2-polarized macrophages

Toll-like receptor 2-mediated ERK activation significantly upregulates interleukin-6 expression in M2-polarized macrophages

M2-polarized macrophages and interleukin (IL)-6 significantly alter the tumor microenvironment and promote the malignant behaviors of tumor cells. This study aimed to establish M2-type macrophages from THP-1 cells, which are human leukemia monocytes, and investigate the significance of toll-like rec...

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Bibliographic Details
Main Authors: Jo Wol Soon, Kim Sung Dae, Jeong Soo Kyung, Oh Su Jung, Baik Ji Sue, Seo Ji An, Baek Jeong-Hwa, Lee Chang Geun, Kang Young-Rok, Jeong Min Ho, Park Moon-Taek
Format: Article
Language:English
Published: De Gruyter 2024-10-01
Series:Türk Biyokimya Dergisi
Subjects:
tlr2
il-6
erk
m2 macrophage
Online Access:https://doi.org/10.1515/tjb-2024-0105
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https://doi.org/10.1515/tjb-2024-0105

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