Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels
Abstract Background Prevalence of metabolic disorders has been increased in recent years around the world. The relationship between Mediterranean diet (MD) with metabolic health status and serum adropin levels has been less examined in Iranian adults. We investigated the association between MD compl...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12889-025-21299-1 |
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| author | Maryam Shafiei Donya Poursalehi Sobhan Mohammadi Farnaz Shahdadian Zahra Hajhashemy Parisa Rouhani Elahe Mokhtari Parvane Saneei |
| author_facet | Maryam Shafiei Donya Poursalehi Sobhan Mohammadi Farnaz Shahdadian Zahra Hajhashemy Parisa Rouhani Elahe Mokhtari Parvane Saneei |
| author_sort | Maryam Shafiei |
| collection | DOAJ |
| description | Abstract Background Prevalence of metabolic disorders has been increased in recent years around the world. The relationship between Mediterranean diet (MD) with metabolic health status and serum adropin levels has been less examined in Iranian adults. We investigated the association between MD compliance with metabolic health status and adropin hormone in Iranian adults. Methods This observational study was conducted on 527 men and women. Food intakes were evaluated by a validated food frequency questionnaire. Blood pressure and anthropometric parameters were measured. Fasting blood samples were drawn to measure serum adropin concentrations, blood glucose, triglycerides, high-density lipoprotein cholesterol, high sensitive C-reactive protein and insulin. Metabolic unhealthy (MU) status was defined as having ≥ 2 cardio-metabolic risk factors. Results After adjustments for potential confounders, subjects in highest versus lowest tertile of MD had 52% lower odds of MU status (OR = 0.48, 95%CI: 0.23–0.97). Stratified analysis revealed a significant association in normal-weight participants (OR = 0.12; 95%CI: 0.02–0.64), but not in those with overweight/obesity (OR = 0.66, 95%CI: 0.27–1.57). By excluding each component of MD, the association disappeared, except for three components (vegetables, nuts and grains). MD adherence was not significantly related to serum adropin levels in multivariable-adjusted model (unstandardized B= -0.19, 95%CI: -4.97, 4.59; P = 0.94). Serum adropin hormone levels were also not substantially different among metabolic healthy versus unhealthy subjects (P = 0.66). Conclusions This cross-sectional study showed an inverse association between adherence to MD and odds of MU status, especially in subjects with normal-weight. Serum adropin concentrations were not associated with MD adherence or metabolic health status. |
| format | Article |
| id | doaj-art-5b89df1329ad437d836a69c55e35b96f |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Public Health |
| spelling | doaj-art-5b89df1329ad437d836a69c55e35b96f2025-01-19T12:41:52ZengBMCBMC Public Health1471-24582025-01-0125111210.1186/s12889-025-21299-1Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levelsMaryam Shafiei0Donya Poursalehi1Sobhan Mohammadi2Farnaz Shahdadian3Zahra Hajhashemy4Parisa Rouhani5Elahe Mokhtari6Parvane Saneei7Students’ Research Committee, Isfahan University of Medical SciencesStudents’ Research Committee, Isfahan University of Medical SciencesDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical SciencesStudents’ Research Committee, Isfahan University of Medical SciencesAdelaide Medical School, Faculty of Health and Medical Sciences, University of AdelaideDepartment of Nutrition, School of Public Health, Iran University of Medical SciencesDepartment of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical SciencesAbstract Background Prevalence of metabolic disorders has been increased in recent years around the world. The relationship between Mediterranean diet (MD) with metabolic health status and serum adropin levels has been less examined in Iranian adults. We investigated the association between MD compliance with metabolic health status and adropin hormone in Iranian adults. Methods This observational study was conducted on 527 men and women. Food intakes were evaluated by a validated food frequency questionnaire. Blood pressure and anthropometric parameters were measured. Fasting blood samples were drawn to measure serum adropin concentrations, blood glucose, triglycerides, high-density lipoprotein cholesterol, high sensitive C-reactive protein and insulin. Metabolic unhealthy (MU) status was defined as having ≥ 2 cardio-metabolic risk factors. Results After adjustments for potential confounders, subjects in highest versus lowest tertile of MD had 52% lower odds of MU status (OR = 0.48, 95%CI: 0.23–0.97). Stratified analysis revealed a significant association in normal-weight participants (OR = 0.12; 95%CI: 0.02–0.64), but not in those with overweight/obesity (OR = 0.66, 95%CI: 0.27–1.57). By excluding each component of MD, the association disappeared, except for three components (vegetables, nuts and grains). MD adherence was not significantly related to serum adropin levels in multivariable-adjusted model (unstandardized B= -0.19, 95%CI: -4.97, 4.59; P = 0.94). Serum adropin hormone levels were also not substantially different among metabolic healthy versus unhealthy subjects (P = 0.66). Conclusions This cross-sectional study showed an inverse association between adherence to MD and odds of MU status, especially in subjects with normal-weight. Serum adropin concentrations were not associated with MD adherence or metabolic health status.https://doi.org/10.1186/s12889-025-21299-1Mediterranean dietMetabolic health statusAdropinAdults |
| spellingShingle | Maryam Shafiei Donya Poursalehi Sobhan Mohammadi Farnaz Shahdadian Zahra Hajhashemy Parisa Rouhani Elahe Mokhtari Parvane Saneei Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels BMC Public Health Mediterranean diet Metabolic health status Adropin Adults |
| title | Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels |
| title_full | Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels |
| title_fullStr | Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels |
| title_full_unstemmed | Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels |
| title_short | Association between Mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels |
| title_sort | association between mediterranean diet and metabolic health status among adults was not mediated through serum adropin levels |
| topic | Mediterranean diet Metabolic health status Adropin Adults |
| url | https://doi.org/10.1186/s12889-025-21299-1 |
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