Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy
Cardiovascular disease, especially coronary artery disease and stroke, kills around one-third of the world’s population, and myocardial infarction, a primary symptom of coronary heart disease, is a major worldwide health problem. Cardiovascular disease research has historically focused on promoting...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/6558060 |
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| _version_ | 1832554936438620160 |
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| author | Mingyue Wu Zixia Huang Lijin Zeng Chunfei Wang Deming Wang |
| author_facet | Mingyue Wu Zixia Huang Lijin Zeng Chunfei Wang Deming Wang |
| author_sort | Mingyue Wu |
| collection | DOAJ |
| description | Cardiovascular disease, especially coronary artery disease and stroke, kills around one-third of the world’s population, and myocardial infarction, a primary symptom of coronary heart disease, is a major worldwide health problem. Cardiovascular disease research has historically focused on promoting angiogenesis following myocardial damage. Myocardial vascular repair is crucial for improving myocardial infarction prognosis. Endothelial cells, the largest population of nonmyocytes within myocardial tissue, play an important role in angiogenesis. In recent years, different types of programmed cell death such as apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy have been described and found to be linked with cardiovascular diseases such as myocardial infarction, heart failure, and myocarditis. This will have important implications for reforming the treatment strategy of cardiovascular diseases. Different types of cell death of endothelial cells in myocardial infarction have been proposed, the roles and mechanisms of endothelial cell death in myocardial infarction are summarized in this review, and endothelial cell death inhibition as a therapeutic technique for treating myocardial infarction might be advantageous to human health. |
| format | Article |
| id | doaj-art-5b68f065f382458fb2bcc45c0297fc8a |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-5b68f065f382458fb2bcc45c0297fc8a2025-02-03T05:50:03ZengWileyCardiology Research and Practice2090-05972022-01-01202210.1155/2022/6558060Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic StrategyMingyue Wu0Zixia Huang1Lijin Zeng2Chunfei Wang3Deming Wang4Department of AnesthesiologyDepartment of AnesthesiologyDepartment of EmergencyEndoscopy CenterDepartment of AnesthesiologyCardiovascular disease, especially coronary artery disease and stroke, kills around one-third of the world’s population, and myocardial infarction, a primary symptom of coronary heart disease, is a major worldwide health problem. Cardiovascular disease research has historically focused on promoting angiogenesis following myocardial damage. Myocardial vascular repair is crucial for improving myocardial infarction prognosis. Endothelial cells, the largest population of nonmyocytes within myocardial tissue, play an important role in angiogenesis. In recent years, different types of programmed cell death such as apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy have been described and found to be linked with cardiovascular diseases such as myocardial infarction, heart failure, and myocarditis. This will have important implications for reforming the treatment strategy of cardiovascular diseases. Different types of cell death of endothelial cells in myocardial infarction have been proposed, the roles and mechanisms of endothelial cell death in myocardial infarction are summarized in this review, and endothelial cell death inhibition as a therapeutic technique for treating myocardial infarction might be advantageous to human health.http://dx.doi.org/10.1155/2022/6558060 |
| spellingShingle | Mingyue Wu Zixia Huang Lijin Zeng Chunfei Wang Deming Wang Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy Cardiology Research and Practice |
| title | Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy |
| title_full | Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy |
| title_fullStr | Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy |
| title_full_unstemmed | Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy |
| title_short | Programmed Cell Death of Endothelial Cells in Myocardial Infarction and Its Potential Therapeutic Strategy |
| title_sort | programmed cell death of endothelial cells in myocardial infarction and its potential therapeutic strategy |
| url | http://dx.doi.org/10.1155/2022/6558060 |
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