Utilizing sc-linker to integrate single-cell RNA sequencing and human genetics to identify cell types and driver genes associated with non-small cell lung cancer

Utilizing sc-linker to integrate single-cell RNA sequencing and human genetics to identify cell types and driver genes associated with non-small cell lung cancer

Abstract Background Genome-wide association studies (GWAS) provide a powerful method for identifying the loci and genes that contribute to disease. However, in many cases, the specific cell types and states that confer disease risk through these genes remain unknown. Determining this relationship is...

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Bibliographic Details
Main Authors: Yangfan Zhou, Liang Zhao, Meimei Cai, Doudou Luo, Yizhen Pang, Jianhao Chen, Qicong Luo, Qin Lin
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
Sc-linker
Single cell RNA seq
CAFs
NSCLC
RAB31
Online Access:https://doi.org/10.1186/s12885-025-13525-1
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https://doi.org/10.1186/s12885-025-13525-1

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