Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X.
The prevalence of obesity (body mass index (BMI) > or =30 kg/m(2)) is higher in African Americans than in European Americans, even after adjustment for socioeconomic factors, suggesting that genetic factors may explain some of the difference. To identify genetic loci influencing BMI, we carried o...
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Public Library of Science (PLoS)
2009-05-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000490&type=printable |
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| author | Ching-Yu Cheng W H Linda Kao Nick Patterson Arti Tandon Christopher A Haiman Tamara B Harris Chao Xing Esther M John Christine B Ambrosone Frederick L Brancati Josef Coresh Michael F Press Rulan S Parekh Michael J Klag Lucy A Meoni Wen-Chi Hsueh Laura Fejerman Ludmila Pawlikowska Matthew L Freedman Lina H Jandorf Elisa V Bandera Gregory L Ciupak Michael A Nalls Ermeg L Akylbekova Eric S Orwoll Tennille S Leak Iva Miljkovic Rongling Li Giske Ursin Leslie Bernstein Kristin Ardlie Herman A Taylor Eric Boerwinckle Joseph M Zmuda Brian E Henderson James G Wilson David Reich |
| author_facet | Ching-Yu Cheng W H Linda Kao Nick Patterson Arti Tandon Christopher A Haiman Tamara B Harris Chao Xing Esther M John Christine B Ambrosone Frederick L Brancati Josef Coresh Michael F Press Rulan S Parekh Michael J Klag Lucy A Meoni Wen-Chi Hsueh Laura Fejerman Ludmila Pawlikowska Matthew L Freedman Lina H Jandorf Elisa V Bandera Gregory L Ciupak Michael A Nalls Ermeg L Akylbekova Eric S Orwoll Tennille S Leak Iva Miljkovic Rongling Li Giske Ursin Leslie Bernstein Kristin Ardlie Herman A Taylor Eric Boerwinckle Joseph M Zmuda Brian E Henderson James G Wilson David Reich |
| author_sort | Ching-Yu Cheng |
| collection | DOAJ |
| description | The prevalence of obesity (body mass index (BMI) > or =30 kg/m(2)) is higher in African Americans than in European Americans, even after adjustment for socioeconomic factors, suggesting that genetic factors may explain some of the difference. To identify genetic loci influencing BMI, we carried out a pooled analysis of genome-wide admixture mapping scans in 15,280 African Americans from 14 epidemiologic studies. Samples were genotyped at a median of 1,411 ancestry-informative markers. After adjusting for age, sex, and study, BMI was analyzed both as a dichotomized (top 20% versus bottom 20%) and a continuous trait. We found that a higher percentage of European ancestry was significantly correlated with lower BMI (rho = -0.042, P = 1.6x10(-7)). In the dichotomized analysis, we detected two loci on chromosome X as associated with increased African ancestry: the first at Xq25 (locus-specific LOD = 5.94; genome-wide score = 3.22; case-control Z = -3.94); and the second at Xq13.1 (locus-specific LOD = 2.22; case-control Z = -4.62). Quantitative analysis identified a third locus at 5q13.3 where higher BMI was highly significantly associated with greater European ancestry (locus-specific LOD = 6.27; genome-wide score = 3.46). Further mapping studies with dense sets of markers will be necessary to identify the alleles in these regions of chromosomes X and 5 that may be associated with variation in BMI. |
| format | Article |
| id | doaj-art-5b4dc2be32a04df48cedd719a2d88a11 |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2009-05-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-5b4dc2be32a04df48cedd719a2d88a112025-08-20T02:17:24ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042009-05-0155e100049010.1371/journal.pgen.1000490Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X.Ching-Yu ChengW H Linda KaoNick PattersonArti TandonChristopher A HaimanTamara B HarrisChao XingEsther M JohnChristine B AmbrosoneFrederick L BrancatiJosef CoreshMichael F PressRulan S ParekhMichael J KlagLucy A MeoniWen-Chi HsuehLaura FejermanLudmila PawlikowskaMatthew L FreedmanLina H JandorfElisa V BanderaGregory L CiupakMichael A NallsErmeg L AkylbekovaEric S OrwollTennille S LeakIva MiljkovicRongling LiGiske UrsinLeslie BernsteinKristin ArdlieHerman A TaylorEric BoerwinckleJoseph M ZmudaBrian E HendersonJames G WilsonDavid ReichThe prevalence of obesity (body mass index (BMI) > or =30 kg/m(2)) is higher in African Americans than in European Americans, even after adjustment for socioeconomic factors, suggesting that genetic factors may explain some of the difference. To identify genetic loci influencing BMI, we carried out a pooled analysis of genome-wide admixture mapping scans in 15,280 African Americans from 14 epidemiologic studies. Samples were genotyped at a median of 1,411 ancestry-informative markers. After adjusting for age, sex, and study, BMI was analyzed both as a dichotomized (top 20% versus bottom 20%) and a continuous trait. We found that a higher percentage of European ancestry was significantly correlated with lower BMI (rho = -0.042, P = 1.6x10(-7)). In the dichotomized analysis, we detected two loci on chromosome X as associated with increased African ancestry: the first at Xq25 (locus-specific LOD = 5.94; genome-wide score = 3.22; case-control Z = -3.94); and the second at Xq13.1 (locus-specific LOD = 2.22; case-control Z = -4.62). Quantitative analysis identified a third locus at 5q13.3 where higher BMI was highly significantly associated with greater European ancestry (locus-specific LOD = 6.27; genome-wide score = 3.46). Further mapping studies with dense sets of markers will be necessary to identify the alleles in these regions of chromosomes X and 5 that may be associated with variation in BMI.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000490&type=printable |
| spellingShingle | Ching-Yu Cheng W H Linda Kao Nick Patterson Arti Tandon Christopher A Haiman Tamara B Harris Chao Xing Esther M John Christine B Ambrosone Frederick L Brancati Josef Coresh Michael F Press Rulan S Parekh Michael J Klag Lucy A Meoni Wen-Chi Hsueh Laura Fejerman Ludmila Pawlikowska Matthew L Freedman Lina H Jandorf Elisa V Bandera Gregory L Ciupak Michael A Nalls Ermeg L Akylbekova Eric S Orwoll Tennille S Leak Iva Miljkovic Rongling Li Giske Ursin Leslie Bernstein Kristin Ardlie Herman A Taylor Eric Boerwinckle Joseph M Zmuda Brian E Henderson James G Wilson David Reich Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. PLoS Genetics |
| title | Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. |
| title_full | Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. |
| title_fullStr | Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. |
| title_full_unstemmed | Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. |
| title_short | Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X. |
| title_sort | admixture mapping of 15 280 african americans identifies obesity susceptibility loci on chromosomes 5 and x |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000490&type=printable |
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