Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation
Excessive fibrosis is the primary factor for the failure of glaucoma drainage device (GDD) implantation. Thus, strategies to suppress scar formation in GDD implantation are crucial. Although it is known that in implanted medical devices, microscale modification of the implant surface can modulate ce...
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0561 |
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| author | Yiling Han Qiangwang Geng Aimeng Dong Menglu Jiang Jingyi Ma Wulian Song Pan Fan Yuanyuan Li Jiawen Gao Fenghua Zhang Jinsong Leng Huiping Yuan |
| author_facet | Yiling Han Qiangwang Geng Aimeng Dong Menglu Jiang Jingyi Ma Wulian Song Pan Fan Yuanyuan Li Jiawen Gao Fenghua Zhang Jinsong Leng Huiping Yuan |
| author_sort | Yiling Han |
| collection | DOAJ |
| description | Excessive fibrosis is the primary factor for the failure of glaucoma drainage device (GDD) implantation. Thus, strategies to suppress scar formation in GDD implantation are crucial. Although it is known that in implanted medical devices, microscale modification of the implant surface can modulate cell behavior and reduce the incidence of fibrosis, in the field of ophthalmic implants, especially the modification and effects of hydrogel micropatterns have rarely been reported. Here, we designed the patterned gelatin/acrylamide double network hydrogel and developed an innovative GDD with micropattern to suppress inflammatory and fibroblast activation after GDD implantation. Pattern topography suppressed F-actin expression and mitigated actin-dependent nuclear migration of myocardin-related transcription factor A (MRTF-A) during the proliferative phase after GDD implantation. Ultimately, the expression of α-smooth muscle actin (α-SMA), a key fibrosis-related gene product, was suppressed. Moreover, the modified GDD effectively controlled intraocular pressure (IOP), mitigated fibrous formation, and remodeled extracellular matrix (ECM) collagen distribution in vivo. Therefore, the novel GDD with surface patterning interventions provides a promising strategy to inhibit scar formation after GDD implantation and raise the efficacy of GDD implantation. |
| format | Article |
| id | doaj-art-5aedff0a9ab24468a0398cee62ae2a19 |
| institution | Kabale University |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-5aedff0a9ab24468a0398cee62ae2a192025-01-22T08:01:16ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0561Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device ImplantationYiling Han0Qiangwang Geng1Aimeng Dong2Menglu Jiang3Jingyi Ma4Wulian Song5Pan Fan6Yuanyuan Li7Jiawen Gao8Fenghua Zhang9Jinsong Leng10Huiping Yuan11Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People’s Republic of China.Centre for Composite Materials and Structures, Harbin Institute of Technology (HIT), Harbin 150080, People’s Republic of China.Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People’s Republic of China.Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People’s Republic of China.Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People’s Republic of China.Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People’s Republic of China.Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People’s Republic of China.Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People’s Republic of China.Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People’s Republic of China.Centre for Composite Materials and Structures, Harbin Institute of Technology (HIT), Harbin 150080, People’s Republic of China.Centre for Composite Materials and Structures, Harbin Institute of Technology (HIT), Harbin 150080, People’s Republic of China.Department of Ophthalmology, The Future Medicine Laboratory, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, People’s Republic of China.Excessive fibrosis is the primary factor for the failure of glaucoma drainage device (GDD) implantation. Thus, strategies to suppress scar formation in GDD implantation are crucial. Although it is known that in implanted medical devices, microscale modification of the implant surface can modulate cell behavior and reduce the incidence of fibrosis, in the field of ophthalmic implants, especially the modification and effects of hydrogel micropatterns have rarely been reported. Here, we designed the patterned gelatin/acrylamide double network hydrogel and developed an innovative GDD with micropattern to suppress inflammatory and fibroblast activation after GDD implantation. Pattern topography suppressed F-actin expression and mitigated actin-dependent nuclear migration of myocardin-related transcription factor A (MRTF-A) during the proliferative phase after GDD implantation. Ultimately, the expression of α-smooth muscle actin (α-SMA), a key fibrosis-related gene product, was suppressed. Moreover, the modified GDD effectively controlled intraocular pressure (IOP), mitigated fibrous formation, and remodeled extracellular matrix (ECM) collagen distribution in vivo. Therefore, the novel GDD with surface patterning interventions provides a promising strategy to inhibit scar formation after GDD implantation and raise the efficacy of GDD implantation.https://spj.science.org/doi/10.34133/research.0561 |
| spellingShingle | Yiling Han Qiangwang Geng Aimeng Dong Menglu Jiang Jingyi Ma Wulian Song Pan Fan Yuanyuan Li Jiawen Gao Fenghua Zhang Jinsong Leng Huiping Yuan Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation Research |
| title | Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation |
| title_full | Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation |
| title_fullStr | Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation |
| title_full_unstemmed | Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation |
| title_short | Anti-Scar Effects of Micropatterned Hydrogel after Glaucoma Drainage Device Implantation |
| title_sort | anti scar effects of micropatterned hydrogel after glaucoma drainage device implantation |
| url | https://spj.science.org/doi/10.34133/research.0561 |
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