Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration
After peripheral nerve injury, a process of axonal degradation, debris clearance, and subsequent regeneration is initiated by complex local signaling, called Wallerian degeneration (WD). This process is in part mediated by neuroglia as well as infiltrating inflammatory cells and regulated by inflamm...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/168953 |
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| author | Carlos Rodrigo Camara-Lemarroy Emmanuel Irineo Gonzalez-Moreno Francisco Javier Guzman-de la Garza Nancy Esthela Fernandez-Garza |
| author_facet | Carlos Rodrigo Camara-Lemarroy Emmanuel Irineo Gonzalez-Moreno Francisco Javier Guzman-de la Garza Nancy Esthela Fernandez-Garza |
| author_sort | Carlos Rodrigo Camara-Lemarroy |
| collection | DOAJ |
| description | After peripheral nerve injury, a process of axonal degradation, debris clearance, and subsequent regeneration is initiated by complex local signaling, called Wallerian degeneration (WD). This process is in part mediated by neuroglia as well as infiltrating inflammatory cells and regulated by inflammatory mediators such as cytokines, chemokines, and the activation of transcription factors also related to the inflammatory response. Part of this neuroimmune signaling is mediated by the innate immune system, including arachidonic acid (AA) derivatives such as prostaglandins and leukotrienes. The enzymes responsible for their production, cyclooxygenases and lipooxygenases, also participate in nerve degeneration and regeneration. The interactions between signals for nerve regeneration and neuroinflammation go all the way down to the molecular level. In this paper, we discuss the role that AA derivatives might play during WD and nerve regeneration, and the therapeutic possibilities that arise. |
| format | Article |
| id | doaj-art-5ada99bb6b104bd0944bef156a5b8c0c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-5ada99bb6b104bd0944bef156a5b8c0c2025-02-03T01:01:16ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/168953168953Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and RegenerationCarlos Rodrigo Camara-Lemarroy0Emmanuel Irineo Gonzalez-Moreno1Francisco Javier Guzman-de la Garza2Nancy Esthela Fernandez-Garza3Departamento de Medicina Interna, Hospital Universitario “José Eleuterio González”, Universidad Autónoma de Nuevo León, School of Medicine, Avenida Francisco I. Madero y Dr. Eduardo Aguirre Pequeño S/No, Colonia Mitras Centro, 64460 Monterrey, Nuevo León, MexicoDepartamento de Medicina Interna, Hospital Universitario “José Eleuterio González”, Universidad Autónoma de Nuevo León, School of Medicine, Avenida Francisco I. Madero y Dr. Eduardo Aguirre Pequeño S/No, Colonia Mitras Centro, 64460 Monterrey, Nuevo León, MexicoDepartamento de Fisiologia, Hospital Universitario “José Eleuterio González”, Universidad Autónoma de Nuevo León, School of Medicine, Avenida Francisco I. Madero y Dr. Eduardo Aguirre Pequeño S/No, Colonia Mitras Centro, 64460 Monterrey, Nuevo León, MexicoDepartamento de Fisiologia, Hospital Universitario “José Eleuterio González”, Universidad Autónoma de Nuevo León, School of Medicine, Avenida Francisco I. Madero y Dr. Eduardo Aguirre Pequeño S/No, Colonia Mitras Centro, 64460 Monterrey, Nuevo León, MexicoAfter peripheral nerve injury, a process of axonal degradation, debris clearance, and subsequent regeneration is initiated by complex local signaling, called Wallerian degeneration (WD). This process is in part mediated by neuroglia as well as infiltrating inflammatory cells and regulated by inflammatory mediators such as cytokines, chemokines, and the activation of transcription factors also related to the inflammatory response. Part of this neuroimmune signaling is mediated by the innate immune system, including arachidonic acid (AA) derivatives such as prostaglandins and leukotrienes. The enzymes responsible for their production, cyclooxygenases and lipooxygenases, also participate in nerve degeneration and regeneration. The interactions between signals for nerve regeneration and neuroinflammation go all the way down to the molecular level. In this paper, we discuss the role that AA derivatives might play during WD and nerve regeneration, and the therapeutic possibilities that arise.http://dx.doi.org/10.1100/2012/168953 |
| spellingShingle | Carlos Rodrigo Camara-Lemarroy Emmanuel Irineo Gonzalez-Moreno Francisco Javier Guzman-de la Garza Nancy Esthela Fernandez-Garza Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration The Scientific World Journal |
| title | Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration |
| title_full | Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration |
| title_fullStr | Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration |
| title_full_unstemmed | Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration |
| title_short | Arachidonic Acid Derivatives and Their Role in Peripheral Nerve Degeneration and Regeneration |
| title_sort | arachidonic acid derivatives and their role in peripheral nerve degeneration and regeneration |
| url | http://dx.doi.org/10.1100/2012/168953 |
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