Down but Not Out: The Consequences of Pretangle Tau in the Locus Coeruleus
Degeneration of locus coeruleus (LC) is an underappreciated hallmark of Alzheimer’s disease (AD). The LC is the main source of norepinephrine (NE) in the forebrain, and its degeneration is highly correlated with cognitive impairment and amyloid-beta (Aβ) and tangle pathology. Hyperphosphorylated tau...
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Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Wiley
2017-01-01
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Series: | Neural Plasticity |
Online Access: | http://dx.doi.org/10.1155/2017/7829507 |
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