Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy
We congratulate Lang and colleagues for their study investigating the impact of resection margin (RM) size on locoregional control (LC) outcomes, overall survival (OS), progression-free survival (PFS), and treatment-related toxicity in 162 patients with oral cavity squamous cell carcinoma (OCSCC) wh...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338241305823 |
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| author | Erkan Topkan MD Efsun Somay PhD Ugur Selek MD |
| author_facet | Erkan Topkan MD Efsun Somay PhD Ugur Selek MD |
| author_sort | Erkan Topkan MD |
| collection | DOAJ |
| description | We congratulate Lang and colleagues for their study investigating the impact of resection margin (RM) size on locoregional control (LC) outcomes, overall survival (OS), progression-free survival (PFS), and treatment-related toxicity in 162 patients with oral cavity squamous cell carcinoma (OCSCC) who received postoperative radiotherapy (PORT).1 In this study, 77 (47.5%), 22 (13.6%), and 63 (38.9%) patients had involved (5 mm) RM, respectively. A RM of ≤5 mm was found to be a significant predictor for worse LC (HR 2.6), but not for OS (HR 1.2) or PFS (HR 1.2). The findings of this study provide important insights into how the status of RM affects the local control and survival outcomes of OCSCC patients who undergo PORT. However, we have two concerns that we believe need to be addressed to interpret the results more comprehensively and guide future research on this critical topic. |
| format | Article |
| id | doaj-art-5a89ed8c9d3942d6a0c9e14ad2d63416 |
| institution | Kabale University |
| issn | 1533-0338 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj-art-5a89ed8c9d3942d6a0c9e14ad2d634162025-02-04T15:03:34ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382025-02-012410.1177/15330338241305823Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative RadiotherapyErkan Topkan MD0Efsun Somay PhD1Ugur Selek MD2 Department of Radiation Oncology, , Adana, Turkey Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, , Ankara, Turkey , , Istanbul, TurkeyWe congratulate Lang and colleagues for their study investigating the impact of resection margin (RM) size on locoregional control (LC) outcomes, overall survival (OS), progression-free survival (PFS), and treatment-related toxicity in 162 patients with oral cavity squamous cell carcinoma (OCSCC) who received postoperative radiotherapy (PORT).1 In this study, 77 (47.5%), 22 (13.6%), and 63 (38.9%) patients had involved (5 mm) RM, respectively. A RM of ≤5 mm was found to be a significant predictor for worse LC (HR 2.6), but not for OS (HR 1.2) or PFS (HR 1.2). The findings of this study provide important insights into how the status of RM affects the local control and survival outcomes of OCSCC patients who undergo PORT. However, we have two concerns that we believe need to be addressed to interpret the results more comprehensively and guide future research on this critical topic.https://doi.org/10.1177/15330338241305823 |
| spellingShingle | Erkan Topkan MD Efsun Somay PhD Ugur Selek MD Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy Technology in Cancer Research & Treatment |
| title | Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy |
| title_full | Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy |
| title_fullStr | Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy |
| title_full_unstemmed | Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy |
| title_short | Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy |
| title_sort | oral cavity squamous cell carcinoma impact of clear margin distance on locoregional control in patients undergoing postoperative radiotherapy |
| url | https://doi.org/10.1177/15330338241305823 |
| work_keys_str_mv | AT erkantopkanmd oralcavitysquamouscellcarcinomaimpactofclearmargindistanceonlocoregionalcontrolinpatientsundergoingpostoperativeradiotherapy AT efsunsomayphd oralcavitysquamouscellcarcinomaimpactofclearmargindistanceonlocoregionalcontrolinpatientsundergoingpostoperativeradiotherapy AT ugurselekmd oralcavitysquamouscellcarcinomaimpactofclearmargindistanceonlocoregionalcontrolinpatientsundergoingpostoperativeradiotherapy |