Diagnostic Performance of Positron Emission Tomography/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis
Purpose. The diagnostic performance of positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) in detecting nodal involvement in patients with anal canal cancer (ACC) has been investigated by several studies with conflicting results. The aim of our study is to systematically review and m...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/196068 |
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| author | Carmelo Caldarella Salvatore Annunziata Giorgio Treglia Ramin Sadeghi Narjes Ayati Luca Giovanella |
| author_facet | Carmelo Caldarella Salvatore Annunziata Giorgio Treglia Ramin Sadeghi Narjes Ayati Luca Giovanella |
| author_sort | Carmelo Caldarella |
| collection | DOAJ |
| description | Purpose. The diagnostic performance of positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) in detecting nodal involvement in patients with anal canal cancer (ACC) has been investigated by several studies with conflicting results. The aim of our study is to systematically review and meta-analyze published data about this topic. Methods. A comprehensive computer literature search of PubMed/MEDLINE, Scopus, and Embase databases was carried out on July 10 to find relevant articles concerning the diagnostic performance of FDG-PET in detecting locoregional nodal involvement in patients with ACC. No language restriction was used. Pooled diagnostic performance on a lesion-based analysis was calculated. Results. Seven retrospective and five prospective studies have been reviewed. Six studies allowed assessing pooled sensitivity; five studies allowed assessing pooled specificity. Sensitivity and specificity values of FDG-PET/CT on a lesion-based analysis ranged from 31 to 100% and from 53 to 98%, with pooled estimates of 56% (95% CI: 45–67%) and 90% (95% CI: 86–93%), respectively. Conclusions. Our meta-analysis demonstrates that FDG-PET is a specific diagnostic tool in detecting locoregional lymph node involvement in patients with ACC. Low sensitivity is a major concern; however, higher sensitivity could be reached combining FDG-PET with MR scan. |
| format | Article |
| id | doaj-art-59cf9b6c217c4a0a8c73b71f2deefc3b |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-59cf9b6c217c4a0a8c73b71f2deefc3b2025-02-03T06:12:53ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/196068196068Diagnostic Performance of Positron Emission Tomography/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-AnalysisCarmelo Caldarella0Salvatore Annunziata1Giorgio Treglia2Ramin Sadeghi3Narjes Ayati4Luca Giovanella5Institute of Nuclear Medicine, Department of Radiological Sciences, Università Cattolica del Sacro Cuore, Rome, ItalyInstitute of Nuclear Medicine, Department of Radiological Sciences, Università Cattolica del Sacro Cuore, Rome, ItalyDepartment of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, SwitzerlandNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, SwitzerlandPurpose. The diagnostic performance of positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) in detecting nodal involvement in patients with anal canal cancer (ACC) has been investigated by several studies with conflicting results. The aim of our study is to systematically review and meta-analyze published data about this topic. Methods. A comprehensive computer literature search of PubMed/MEDLINE, Scopus, and Embase databases was carried out on July 10 to find relevant articles concerning the diagnostic performance of FDG-PET in detecting locoregional nodal involvement in patients with ACC. No language restriction was used. Pooled diagnostic performance on a lesion-based analysis was calculated. Results. Seven retrospective and five prospective studies have been reviewed. Six studies allowed assessing pooled sensitivity; five studies allowed assessing pooled specificity. Sensitivity and specificity values of FDG-PET/CT on a lesion-based analysis ranged from 31 to 100% and from 53 to 98%, with pooled estimates of 56% (95% CI: 45–67%) and 90% (95% CI: 86–93%), respectively. Conclusions. Our meta-analysis demonstrates that FDG-PET is a specific diagnostic tool in detecting locoregional lymph node involvement in patients with ACC. Low sensitivity is a major concern; however, higher sensitivity could be reached combining FDG-PET with MR scan.http://dx.doi.org/10.1155/2014/196068 |
| spellingShingle | Carmelo Caldarella Salvatore Annunziata Giorgio Treglia Ramin Sadeghi Narjes Ayati Luca Giovanella Diagnostic Performance of Positron Emission Tomography/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis The Scientific World Journal |
| title | Diagnostic Performance of Positron Emission Tomography/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis |
| title_full | Diagnostic Performance of Positron Emission Tomography/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis |
| title_fullStr | Diagnostic Performance of Positron Emission Tomography/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Diagnostic Performance of Positron Emission Tomography/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis |
| title_short | Diagnostic Performance of Positron Emission Tomography/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis |
| title_sort | diagnostic performance of positron emission tomography computed tomography using fluorine 18 fluorodeoxyglucose in detecting locoregional nodal involvement in patients with anal canal cancer a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2014/196068 |
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