IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B Streptococcus Infection
IL-4 is an anti-inflammatory cytokine that inhibits the onset and severity in different experimental arthritis models. Group B streptococci (GBS) have been recognized as an ever-growing cause of serious in...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/394021 |
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| _version_ | 1832552013447036928 |
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| author | Luciana Tissi Francesco Bistoni Manuela Puliti |
| author_facet | Luciana Tissi Francesco Bistoni Manuela Puliti |
| author_sort | Luciana Tissi |
| collection | DOAJ |
| description | IL-4 is an
anti-inflammatory cytokine that inhibits the
onset and severity in different experimental
arthritis models. Group B streptococci (GBS)
have been recognized as an ever-growing cause of
serious invasive infections in nonpregnant
adults. Septic arthritis is a clinical
manifestation of GBS infection. To investigate
the role of IL-4 in experimental GBS infection,
IL-4 deficient or competent mice were inoculated
with 1×107 GBS/mouse. Mortality, appearance of arthritis, GBS
growth in the organs, and local and systemic cytokine and
chemokine production were examined. IL-4–/– mice
showed lower mortality rates but increased severity of arthritis
and exhibited a lower microbial load in blood, kidneys, and joints
than wt mice. Increased local levels of IL-1 β, IL-6, TNF-α, MIP-1α, and MIP-2 accompanied the more severe arthritis in IL-4–/– mice. Our results suggest a detrimental role of IL-4 in GBS sepsis, whereas it plays a beneficial effect on GBS-induced arthritis. |
| format | Article |
| id | doaj-art-59ccb505ebde47a6a985f3af0445f04a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-59ccb505ebde47a6a985f3af0445f04a2025-02-03T05:59:50ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/394021394021IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B Streptococcus InfectionLuciana Tissi0Francesco Bistoni1Manuela Puliti2Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, ItalyMicrobiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, ItalyMicrobiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, ItalyIL-4 is an anti-inflammatory cytokine that inhibits the onset and severity in different experimental arthritis models. Group B streptococci (GBS) have been recognized as an ever-growing cause of serious invasive infections in nonpregnant adults. Septic arthritis is a clinical manifestation of GBS infection. To investigate the role of IL-4 in experimental GBS infection, IL-4 deficient or competent mice were inoculated with 1×107 GBS/mouse. Mortality, appearance of arthritis, GBS growth in the organs, and local and systemic cytokine and chemokine production were examined. IL-4–/– mice showed lower mortality rates but increased severity of arthritis and exhibited a lower microbial load in blood, kidneys, and joints than wt mice. Increased local levels of IL-1 β, IL-6, TNF-α, MIP-1α, and MIP-2 accompanied the more severe arthritis in IL-4–/– mice. Our results suggest a detrimental role of IL-4 in GBS sepsis, whereas it plays a beneficial effect on GBS-induced arthritis.http://dx.doi.org/10.1155/2009/394021 |
| spellingShingle | Luciana Tissi Francesco Bistoni Manuela Puliti IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B Streptococcus Infection Mediators of Inflammation |
| title | IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B
Streptococcus Infection |
| title_full | IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B
Streptococcus Infection |
| title_fullStr | IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B
Streptococcus Infection |
| title_full_unstemmed | IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B
Streptococcus Infection |
| title_short | IL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B
Streptococcus Infection |
| title_sort | il 4 deficiency decreases mortality but increases severity of arthritis in experimental group b streptococcus infection |
| url | http://dx.doi.org/10.1155/2009/394021 |
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