Novel In Vitro Selection of <i>Trans</i>-Acting <i>BCL-2</i> mRNA-Cleaving Deoxyribozymes for Cancer Therapy

Novel In Vitro Selection of <i>Trans</i>-Acting <i>BCL-2</i> mRNA-Cleaving Deoxyribozymes for Cancer Therapy

The B Cell Lymphoma-2 (<i>BCL-2</i>) family proteins are central regulators of apoptosis, and their dysregulation is frequently associated with cancer progression and resistance to therapy. While small molecules like venetoclax have shown promise, nucleic acid-based therapeutics targetin...

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Bibliographic Details
Main Authors: Veera Vijaya Basamshetty, Vijay Kumar Gangipangi, Uppulapu Shravan Kumar, Santhosh Shanthi Bhupathi, Sridhar Reddy Kaulagari, Prashant Giri, Swapnil Sinha, Utpal Mohan, Konstantinos Sdrimas
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
DNAzymes
<i>BCL-2</i>
apoptosis
cancer
synthetic biology
Online Access:https://www.mdpi.com/2073-4409/14/13/945
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