Muscle weakness but also contractures contribute to the progressive gait pathology in children with Duchenne muscular dystrophy: a simulation study

Muscle weakness but also contractures contribute to the progressive gait pathology in children with Duchenne muscular dystrophy: a simulation study

Abstract Background Muscle weakness and contractures cause gait deficits in children with Duchenne muscular dystrophy (DMD) but their relative contributions are poorly understood and hence it is unclear whether contractures should be treated. Therefore, we aimed to differentiate the effect of muscle...

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Bibliographic Details
Main Authors: Ines Vandekerckhove, Lars D’Hondt, Dhruv Gupta, Bram Van Den Bosch, Marleen Van den Hauwe, Nathalie Goemans, Liesbeth De Waele, Anja Van Campenhout, Kaat Desloovere, Friedl De Groote
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of NeuroEngineering and Rehabilitation
Subjects:
Duchenne muscular dystrophy
Muscle weakness
Contractures
Musculoskeletal modeling
Predictive simulations
Online Access:https://doi.org/10.1186/s12984-025-01631-x
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https://doi.org/10.1186/s12984-025-01631-x

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