Comparison of the effects of metformin and empagliflozin on cardiac function in heart failure with preserved ejection fraction mice

Comparison of the effects of metformin and empagliflozin on cardiac function in heart failure with preserved ejection fraction mice

PurposeRecent evidence suggests that empagliflozin (EMPA) and metformin (MET) may improve prognosis in heart failure with preserved ejection fraction (HFpEF) patients. This study aims to compare their effects on cardiac structure and function in HFpEF.MethodsMale C57BL/6J mice were fed a high-fat di...

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Main Authors: Xiehong Liu, Huiqi Zhao, Sisi Liu, Siao Wen, Wenjuan Fan, Qiong Xie, Bo Cui, Lin Zhou, Jianqiang Peng, Hongwei Pan, Zhaofen Zheng, Qinghai Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
heart failure with preserved ejection fraction
metformin
empagliflozin
cardiac fibrosis
cardiac hypertrophy
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1533820/full
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https://www.frontiersin.org/articles/10.3389/fcvm.2025.1533820/full

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