Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus

Three-dimensional linkage analysis with digital PCR for genome integrity and identity of recombinant adeno-associated virus

Abstract Recombinant adeno-associated virus (rAAV) has emerged as the vector of choice for in vivo gene delivery, with numerous clinical trials underway for the treatment of various human diseases. Utilizing rAAV in gene therapy requires a highly precise quantification method to determine the viral...

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Bibliographic Details
Main Authors: Tam Duong, Michele Firmo, Chien-Ting Li, Bingnan Gu, Peng Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
AAV
Titer
3D dPCR
Genome integrity
GOI identity
3D linkage analysis
Online Access:https://doi.org/10.1038/s41598-024-77378-7
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https://doi.org/10.1038/s41598-024-77378-7

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