The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response

The differential impact of HNRNPA1 isoforms on gene expression and their relevance to dsRNA-mediated innate immune response

Abstract Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is a highly abundant RNA binding protein alternatively spliced in two main isoforms named, hnRNP A1 and hnRNP A1B. While being ubiquitously expressed, both isoforms have different cellular localizations and are differentially expressed in...

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Main Authors: Jade-Emmanuelle Deshaies, Valérie Triassi, Andréanne Lacombe, Myriam Gagné, Karen Ling, Asmita Ghosh, Marjorie Labrecque, Frank Rigo, Paymaan Jafar-nejad, Martine Tétreault, Christine Vande Velde
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
HNRNPA1
Isoforms
RNA sequencing (RNA-seq)
Differential gene expression
Double-stranded RNA
Innate immunity
Online Access:https://doi.org/10.1038/s41598-025-99031-7
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https://doi.org/10.1038/s41598-025-99031-7

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