Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition

Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition

Abstract Tumor evolution is one of the major mechanisms responsible for acquiring therapy-resistant and more aggressive cancer clones. Whether the tumor microenvironment through immune-mediated mechanisms might promote the development of more aggressive cancer types is crucial for the identification...

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Main Authors: Siddhartha Mukherjee, Cindy Garda, Letizia Boffa, Angela Rita Elia, Matteo Massara, Maria Teresa Balia, Daniela Brina, Simone Mosole, Anna Campagnari, Giada Andrea Cassanmagnago, Andrea Rinaldi, Giacomo Lazzaroni, David Jarrossay, Diego Morone, Ilaria Ceppi, Riccardo De Sillo, Isabella Giacomini, Ilaria Craparotta, Laura Di Rito, Simon Barry, Endre Laczko, Sebastian Streb, Francesco Meani, Simona Di Lascio, Nancy Hynes, Enrico Lugli, Simone Puccio, Stephen-John Sammut, Ulrike Perriard, Yves Harder, Lorenzo Rossi, Maria Luisa Gasparri, Marco Bolis, Petr Cejka, Arianna Calcinotto
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61422-9
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https://doi.org/10.1038/s41467-025-61422-9

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