Association of predicted fat mass, predicted lean mass and predicted percent fat with diabetes mellitus in Chinese population: a 15-year prospective cohort
Objectives With body mass index (BMI) failing to distinguish the mass of fat from lean, several novel predicted equations for predicted fat mass (FM), predicted lean mass (LM) and predicted per cent fat (PF) were recently developed and validated. Our aim was to explore whether the three novel parame...
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BMJ Publishing Group
2022-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e058162.full |
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| author | Lu Liu Xiaoping Chen Chao Ban Shanshan Jia Sen He |
| author_facet | Lu Liu Xiaoping Chen Chao Ban Shanshan Jia Sen He |
| author_sort | Lu Liu |
| collection | DOAJ |
| description | Objectives With body mass index (BMI) failing to distinguish the mass of fat from lean, several novel predicted equations for predicted fat mass (FM), predicted lean mass (LM) and predicted per cent fat (PF) were recently developed and validated. Our aim was to explore whether the three novel parameters could better predict diabetes mellitus (DM) than the commonly used obesity indicators, including BMI, waist circumference, hip circumference and waist-hip ratio.Design A 15-year prospective cohort was used.Setting It was a prospective cohort, consisting of a general Chinese population from 1992 to 2007.Participants This cohort enrolled 711 people. People suffering from DM at baseline (n=24) were excluded, and 687 non-diabetics with complete data were included to the analysis.Primary outcome New-onset DM.Results After the follow-up, 74 (48 men and 26 women) incidences of DM were documented. For men, the adjusted HRs were 1, 5.19 (p=0.003) and 7.67 (p<0.001) across predicted PF tertiles; 1, 2.86 (p=0.029) and 5.60 (p<0.001) across predicted FM tertiles; 1, 1.21 (p=0.646) and 2.27 (p=0.025) across predicted LM tertiles. Predicted FM performed better than other commonly used obesity indicators in discrimination with the highest Harrell’s C-statistic among all the body composition parameters. Whereas, for women, none of the three novel parameters was the independent predictor.Conclusion Predicted PF, predicted LM and predicted FM could independently predict the risk of DM for men, with predicted FM performing better in discrimination than other commonly used obesity indicators. For women, larger samples were further needed. |
| format | Article |
| id | doaj-art-587a0bef42214726a1554d2d6c6ba4f0 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-587a0bef42214726a1554d2d6c6ba4f02025-01-27T16:30:09ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-058162Association of predicted fat mass, predicted lean mass and predicted percent fat with diabetes mellitus in Chinese population: a 15-year prospective cohortLu Liu0Xiaoping Chen1Chao Ban2Shanshan Jia3Sen He41 Department of Rehabilitation, Daping Hospital, Army Medical University, Chongqing, ChinaCardiovascular Department, West China Hospital of Sichuan University, Chengdu, Sichuan, China2 Department of Equipment, Sichuan University West China Hospital, Chengdu, Sichuan, China1 Department of Cardiology, Sichuan University West China Hospital, Chengdu, Sichuan, ChinaDigital Manufacturing Laboratory, Beijing Institute of Technology, Beijing, ChinaObjectives With body mass index (BMI) failing to distinguish the mass of fat from lean, several novel predicted equations for predicted fat mass (FM), predicted lean mass (LM) and predicted per cent fat (PF) were recently developed and validated. Our aim was to explore whether the three novel parameters could better predict diabetes mellitus (DM) than the commonly used obesity indicators, including BMI, waist circumference, hip circumference and waist-hip ratio.Design A 15-year prospective cohort was used.Setting It was a prospective cohort, consisting of a general Chinese population from 1992 to 2007.Participants This cohort enrolled 711 people. People suffering from DM at baseline (n=24) were excluded, and 687 non-diabetics with complete data were included to the analysis.Primary outcome New-onset DM.Results After the follow-up, 74 (48 men and 26 women) incidences of DM were documented. For men, the adjusted HRs were 1, 5.19 (p=0.003) and 7.67 (p<0.001) across predicted PF tertiles; 1, 2.86 (p=0.029) and 5.60 (p<0.001) across predicted FM tertiles; 1, 1.21 (p=0.646) and 2.27 (p=0.025) across predicted LM tertiles. Predicted FM performed better than other commonly used obesity indicators in discrimination with the highest Harrell’s C-statistic among all the body composition parameters. Whereas, for women, none of the three novel parameters was the independent predictor.Conclusion Predicted PF, predicted LM and predicted FM could independently predict the risk of DM for men, with predicted FM performing better in discrimination than other commonly used obesity indicators. For women, larger samples were further needed.https://bmjopen.bmj.com/content/12/6/e058162.full |
| spellingShingle | Lu Liu Xiaoping Chen Chao Ban Shanshan Jia Sen He Association of predicted fat mass, predicted lean mass and predicted percent fat with diabetes mellitus in Chinese population: a 15-year prospective cohort BMJ Open |
| title | Association of predicted fat mass, predicted lean mass and predicted percent fat with diabetes mellitus in Chinese population: a 15-year prospective cohort |
| title_full | Association of predicted fat mass, predicted lean mass and predicted percent fat with diabetes mellitus in Chinese population: a 15-year prospective cohort |
| title_fullStr | Association of predicted fat mass, predicted lean mass and predicted percent fat with diabetes mellitus in Chinese population: a 15-year prospective cohort |
| title_full_unstemmed | Association of predicted fat mass, predicted lean mass and predicted percent fat with diabetes mellitus in Chinese population: a 15-year prospective cohort |
| title_short | Association of predicted fat mass, predicted lean mass and predicted percent fat with diabetes mellitus in Chinese population: a 15-year prospective cohort |
| title_sort | association of predicted fat mass predicted lean mass and predicted percent fat with diabetes mellitus in chinese population a 15 year prospective cohort |
| url | https://bmjopen.bmj.com/content/12/6/e058162.full |
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