Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma

Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma

Abstract Esophageal squamous-cell carcinoma (ESCC) is one of the most common gastrointestinal cancers in China, characterized by high malignancy and poor prognosis. Nowadays, the therapeutic options for this cancer are very limited. Notch-signaling is often overactivated in ESCC, but its role remain...

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Main Authors: Cainan Li, Pujie Wu, Xiaoting Xie, Xinjie Chen, Liping Chen, Liang Zhu, Zhixuan Xuan, Tianyuan Liu, Wen Tan, Shaosen Zhang, Dongxin Lin, Chen Wu
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02309-5
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https://doi.org/10.1038/s41392-025-02309-5

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